2型糖尿病远端对称性多发性神经病变的临床特点及相关因素分析  

Clinical Characteristics and Risk Factors for Distal Symmetric Polyneuropathy among People with Type 2 Diabetes

作　　者：霍丽丽[1] 兰玲[1] 李泉 陈佳[1] 左庆瑶[1] 张国英[1] 邓微[1] Huo Lili;Lan Ling;Li Quan(Department of Endocrinology,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京积水潭医院内分泌科,100035

出　　处：《医学研究杂志》2018年第7期67-70,4,共5页Journal of Medical Research

基　　金：北京市医院管理局"青苗"计划项目(QML20160404);北京市留学人员科技活动择优基金资助项目

摘　　要：目的探讨2型糖尿病并发远端对称性多发性神经病变(DSPN)的患病情况、临床特点及相关危险因素。方法选取2016年1~6月北京积水潭医院门诊或病房明确诊断2型糖尿病并自愿参加糖尿病神经病变筛查的患者160例,根据是否合并DSPN分为DSPN组和非DSPN组,比较两组的临床特点、糖尿病肾病及糖尿病相关合并症的发生情况,采用Logistic回归分析探讨DSPN的危险因素。结果在160例2型糖尿病患者中,共筛查出合并DSPN患者98例,DSPN发生率达61.3%。DSPN组患者的年龄、糖尿病病程和吸烟率高于非DSPN组,且差异均有统计学意义(P<0.05);DSPN组较非DSPN组糖尿病肾病发生率和心脑血管疾病发生率高,且差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示年龄、糖尿病病程、Hb A1c、是否吸烟、是否合并糖尿病肾病以及是否合并心血管疾病与2型糖尿病并发DSPN有关。结论 2型糖尿病患者DSPN发生率高,年龄大、糖尿病病程长、吸烟、糖尿病肾病以及合并心血管疾病是2型糖尿病并发DSPN的危险因素。Objective To explore the prevalence, clinical characteristics and risk factors for distal symmetric polyneuropathy （DSPN） among people with type 2 diabetes. Methods We enrolled 160 people with type 2 diabetes from the clinic or ward of Endocrinology Department of Beijing Jishuitan Hospital between January and June in 2016 who were consent to participate in the screening for diabetic neuropathy. The participants were divided into DSPN group and non-DSPN group according to the screening results. We compared the clinical characteristics, the prevalence of diabetic nephropathy and diabetes related co-morbidities between two groups and apply logistic regression analysis to explore the risk factors of DSPN. Results Among 160 subjects, 98 patients were complicated with DSPN and the prevalence of DSPN was 61.3%. DSPN group was significantly higher （P〈0.05） than non-DSPN group in age, duration of diabetes, smoking rate and the prevalence of diabetic nephropathy and cardio-cerebrovascular disease. Multivariate Logistic regression analysis showed that age, duration of diabetes, HbA1c, smoking, diabetic nephropathy and cardiovascular disease have regression relation with DSPN in people with type 2 diabetes. Conclusion The prevalence of DSPN among people with type 2 diabetes was high. Older age, longer duration of diabetes, smoking, diabetic nephropathy and cardiovascular disease were associated with higher risk of developing DSPN in type 2 diabetes.

关 键 词：2型糖尿病 糖尿病远端对称性多发性神经病变 危险因素 

分 类 号：R5[医药卫生—内科学]