血脂水平对阿尔茨海默病发病风险的指示作用  

The predictive role of lipid profiles in the risk of Alzheimer's disease

作　　者：刘晓芬 吴雨霏 张虹[2] 李军林[1] 张科进[1] LIU Xiao-Fen;WU Yu-Fei;ZHANG Hong(College of Life Science,Institute of Health ＆ Population,Northwest University,Xi＇an 710069,Shaanxi,China)

机构地区：[1]西北大学生命科学学院,陕西西安710069 [2]陕西省人民医院神经内一科

出　　处：《中国老年学杂志》2018年第15期3687-3690,共4页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助项目(31340028;31371327);陕西省社会发展计划项目(2014K11-03-02-01)

摘　　要：目的利用Meta分析的方法系统评价亚洲人群常规血检中的血脂水平与个体阿尔茨海默病(AD)发生的关联性。方法从Pub Med数据库、Web of science数据库、中国学术期刊全文数据库(CNKI)、万方数据库,收集亚洲人群血脂水平相关指标:高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)及三酰甘油(TG)含量与AD的病例-对照研究;提取数据并使用Comprehensive Meta Analysis V2进行统计分析。结果共15个研究合计1 999例研究对象(病例组982例、对照组1 017例)纳入本次Meta分析。结果表明低HDL-C(OR=1.414,95%CI:1.015～1.968,P=0.040),高LDL-C(OR=2.473,95%CI:1.258～4.862,P=0.009)、TC(OR=2.531,95%CI:1.887～3.395,P<0.001)、TG(OR=1.853,95%CI:1.326～2.590,P<0.001)均与AD发生显著相关,可能是其发生风险的因素。结论在亚洲人群中,血脂水平异常对个体的AD发生具有很好的指示作用,血脂水平可作为AD风险评估、患者临床监测及其后期干预等方面的生物学标记。Objective To evaluate the correlation of blood lipid level in routine Mood tests and individual Alzheimer＇s disease（AD） by meta-analyses method in Asian populations. Methods Corresponding data, with ease-control studies of the relevant indicators on blood lipid level （HDL-C, LDL-C,TC and TC,） and AD,were retrieved from the PubMed, Web of science, CNKI and WanFang Data. Meta-analysis was performed by Comprehensive Meta-Analysis V2. Results A total of 15 studies involving 1 999 subjects were included. The low HDL- C （ OR = 0.707, 95 % CI： 0. 508 - 0. 985, P = 0. 040） and high LDL-C （ OR = 2. 473,95 % CI： 1.258 - 4. 862, P = 0.009 ）, TC （ OR = 2.531, 95% CI： 1. 887 - 3. 395 ,P〈0. 001 ） ,TG（ OR= 1. 780, 95% CI： 1. 294 - 2. 448 ,P〈0. 001 ） were significantly correlated with AD, and predicted an increased risk of this disease. Conclusions Abnormal blood lipid is a good indieator of individual AD development, and lipid levels could be used as biomarkers for AD risk assessment, clinical monitoring of patients, and their late intervention in Asian populations.

关 键 词：阿尔茨海默病 血脂 

分 类 号：R18[医药卫生—流行病学]