广西莪术水提取物抗血栓形成作用的实验研究  

Experimental Study on Anti-thrombotic Effect of Aqueous Extract of Ezhu(Curcuma Kwangsiensis)

作　　者：陈晓军 韦洁 农云开 李燕婧 CHEN Xiaojun;WEI Jie;NONG Yunkai;LI Yanjing(Guangxi Institute of Traditional Medical and Pharmaceutical Sciences,Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standard,Nanning,Guangxi 53002)

机构地区：[1]广西壮族自治区中医药研究院,广西壮族自治区中药质量标准研究重点实验室,广西南宁530022

出　　处：《中国中医药科技》2018年第4期495-497,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：广西自然科学基金项目(2013GXNSFAA019262)

摘　　要：目的:探讨广西莪术水提取物抗血栓形成作用。方法:采用胶原蛋白—肾上腺素诱发小鼠体内血栓形成模型,角叉菜胶致小鼠尾部血栓形成模型,大鼠体内静脉血栓形成模型,观察广西莪术水提取物的抗血栓形成作用。结果:广西莪术水提取物对胶原蛋白—肾上腺素诱发的小鼠体内血栓形成有明显的保护作用;明显减少角叉菜胶所致小鼠尾部血栓黑尾动物数,减小黑尾长度;减轻大鼠体内静脉血栓湿重。结论:广西莪术水提取物具有显著的抗血栓形成作用。Objective：To explore the anti-thrombotic effect of aqueous extract of Curcuma Kwangsiensis.Methods：The models of collagen-adrenalin induced mouse＇s thrombus in vivo,the models of carrageenan induced thrombosis in mouse tail and the models of venous thrombosis of rats in vivo were used to observe the anti-thrombotic effect of aqueous extract of Curcuma Kwangsiensis.Results：The aqueous extract of Curcuma Kwangsiensis had obvious protective effect on in vivo thrombus of mouse induced by collagen-adrenalin.It could obviously decrease the carrageenan induced the mouse tail thrombosis,shorten blackened tail number of animals and length,reduce the wet weight of rats in vivo venous thrombosis.Conclusion：Aqueous extract of Curcuma Kwangsiensis have obvious anti-thrombotic effect.

关 键 词：广西莪术 水提取物 抗血栓形成 小鼠 大鼠 

分 类 号：R285.5[医药卫生—中药学]