急性有机磷农药中毒抢救新方案2018  

New solution for acute organophosphorus pesticide poisoning 2018

作　　者：孙伟[1] 赵德禄[2] 张重阳[1] 邱红楠 王耀辉[1] 邱丽娟[1] 

机构地区：[1]秦皇岛市第一医院急诊科,河北秦皇岛066000 [2]军事医学科学院毒物药物研究所

出　　处：《临床急诊杂志》2018年第7期486-488,共3页Journal of Clinical Emergency

摘　　要：近10余年,有机磷农药中毒患者例数已大大减少。但是,急诊重度有机磷中毒患者近2年呈现增加趋势,这就给临床带来两大问题：（1）熟悉急性有机磷中毒抢救的医护人员缺少。经过长期这类农药中毒明显减少后,由于人员的调动,新技术力量的增加,对有机磷中毒的救治已生疏。Acute organophosphorus pesticide poisoning（AOPP）is one of the most common critical illnesses in clinical practice,and the mortality rate is extremely high.Organophosphorus insecticides accumulate acetylcholine（ACh）by inhibiting the activity of acetylcholinesterase（AChE）of the neural linker,causing symptoms of cholinergic poisoning after inhibition.Anticholinergic drugs and AChE regenerative agents should be combined in the early stage of poisoning.Atropine and penehyclidine hydrochloride（long toning）are the most commonly used anticholinergic drugs,which can effectively compete for ACh receptors and play a role in the treatment of cholinergic crisis caused by AOPP;The compound is capable of restoring the inhibited AChE to its activity of hydrolyzing ACh.Recently,under the existing conditions,the traditional anti-poison drugs were recombined to explore a new AOPP rescue plan.

关 键 词：有机磷农药 中毒 抗胆碱能药物 肟类复能剂 

分 类 号：R595.4[医药卫生—内科学]