特异性免疫不同方式给药治疗变应性鼻炎的临床效果观察  

Observation on the Clinical Effect of Different Specific Immunotherapy on the Allergic Rhinitis

作　　者：赵广辉 刘杰[1] 宗国昶 冯小宝[1] 鲁珺 王苑[3] ZHAO Guang-hui;LIU Jie;ZONG Guo-chang;FENG Xiao-bao;LU Jun(Baoji People＇s hospital,Baoji,Shaanxi,721006,China;Staff hospital of cement factory,yao zhou district tongchuan city of Shaanxi province,Tongchuan,Shaanxi,727100,China;Hanzhong Central Hospital,Hanzhong,Shaanxi,723000,China)

机构地区：[1]宝鸡市人民医院,陕西宝鸡721006 [2]陕西省铜川市耀州区水泥厂职工医院,陕西铜川727100 [3]汉中市中心医院,陕西汉中723000

出　　处：《现代生物医学进展》2018年第12期2384-2387,2400,共5页Progress in Modern Biomedicine

基　　金：陕西省科技攻关计划项目(13025647)

摘　　要：目的:研究特异性免疫不同方式给药治疗变应性鼻炎的临床效果及安全性。方法:选取2013年4月-2015年4月我院收治的80例变应性鼻炎患者为研究对象,按照给药方式的不同分为对照组与观察组,对照组给予变应原疫苗皮下免疫治疗,观察组给予变应原滴剂舌下免疫治疗,比较两组患者的治疗效果、症状积分、体征积分、RQLQ评分的改善情况与不良反应的发生情况。结果:观察组患者治疗1年后症状积分、体征积分、RQLQ评分均显著低于对照组(P<0.05),但总有效率显著高于对照组(P<0.01),两组患者均无严重不良反应发生,对照组患者局部不良反应的发生率明显高于观察组(P<0.01)。结论:采用皮下免疫法对变应性鼻炎的治疗效果明显优于舌下免疫治疗,可有效控制患者症状和体征,且安全性更高。Objective： To analyze the clinical effect and safety of specific immunotherapy in the treatment of allergic rhinitis.Methods： 80 cases of patients with allergic rhinitis were selected from April April 2013 to April 2015 in our hospital as the research object and divided into the control group and the observation group according to the different ways of administration. The control group was given subcutaneous allergen vaccine immune therapy, while the observation group was given allergen drops sublingual immunotherapy.The clinical effect, improvement of symptom score, sign score, RQLQ score and the incidence of adverse reactions were compared between two groups. Results： After 1 years of treatment, the symptom score, sign score, RQLQ score of patients in the observation group were significantly lower than those of the control group（P〈0.05）, but the total effective rate was significantly higher than that of the control group（P〈0.01）, no serious adverse reactions was found in both groups of patients, the incidence rate of local adverse reaction in the control group was significantly higher than the observation group（P〈0.01）. Conclusions： The treatment effect of subcutaneous immunization on allergic rhinitis is obviously superior to that of sublingual immunotherapy, it can effectively control the symptoms and signs with higher safety.

关 键 词：变应性鼻炎 变应原特异性治疗 给药方式 效果 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]