地诺前列酮栓联合头孢呋辛治疗足月胎膜早破的临床疗效及对白细胞介素6、C反应蛋白的影响  

Clinical efficacy of dinoprostone suppositories combined with cefuroxime in the treatment of premature rupture of membranes and effects on IL-6 and C reactive protein

作　　者：韩愈 杨心宇[1] 陈晓璐[1] 卢艳梅[1] HAN Yu;YANG Xinyu;CHEN Xiaolu;LU Yanmei(Gynecology Department,First People＇s Hospital of Taizhou,Taizhou 318020,Zhejiang,China)

机构地区：[1]台州市第一人民医院妇产科

出　　处：《中国临床药理学与治疗学》2018年第6期700-703,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：台州市科学技术局基金项目(1701KY50)

摘　　要：目的:探讨地诺前列酮栓联合头孢呋辛治疗足月胎膜早破的临床效果及对白细胞介素6(IL-6)、C反应蛋白(CRP)的影响。方法:将104例足月胎膜早破患者分为研究组和对照组,每组52例。全部患者给予静脉滴注头孢呋辛治疗。对照组采用缩宫素进行引产。观察组采用地诺前列酮栓进行引产。记录两组患者的分娩结局情况,包括阴道分娩/剖宫产、临产时间、总产程、产后出血量、宫内感染;记录两组的新生儿状况,包括新生儿体质量、Apgar评分、胎儿窘迫、新生儿窒息;检测两组患者入院时、分娩后血清CRP、IL-6的水平变化。结果:研究组的总有效率明显高于对照组,差异有统计学意义(P<0.05);研究组的剖宫产、临产时间、总产程、宫内感染明显低于对照组,差异有统计学意义(P<0.05);两组的产后出血量对比,差异无统计学意义(P>0.05);两组的新生儿体质量、Apgar评分、胎儿窘迫、新生儿窒息对比,差异无统计学意义(P>0.05);两组分娩后的CRP明显升高,IL-6明显降低(P<0.05);研究组分娩后的CRP、IL-6明显低于对照组,差异有统计学意义(P<0.05)。结论:地诺前列酮栓联合头孢呋辛治疗足月胎膜早破的疗效确切,能提高阴道分娩率,降低宫内感染率。AIM： To investigate the clinical effect of dinoprostone suppositories combined with cefuroxime in the treatment of preterm premature rupture of membranes and effects on interleukin-6（ IL-6）,C reactive protein（ CRP）. METHODS：One hundred and four cases of premature rupture of membranes were divided into the trial group and the control group,52 cases in each group. All patients were given intravenous infusion of cefuroxime. The control group received oxytocin to induce labor. The trial group was given dinoprostone suppositories for induction. The birth outcomes of the two groups were recorded,including vaginal delivery/cesarean section,labor time,total stage of labor,postpartum hemorrhage and intrauterine infection. Neonatal conditions were observed,including neonatal weight,Apgar score,fetal distress and neonatal asphyxia.The levels of serum CRP and IL-6 were detected in two groups at admission and after labor. RESULTS：The total effective rate of the trial group was significantly higher than that of the control group, the difference was statistically significant（ P〈0. 05）.The cesarean section,labor time,total stage of labor and intrauterine infection in the trial group were significantly lower than those in the control group,the difference was statistically significant（ P〈0. 05）.Comparison of postpartum hemorrhage volume between two groups was not statistically significant（ P〉0. 05）. Comparison of neonatal weight,Apgar score,fetal distress and neonatal asphyxia between the two groups was not statistically significant（ P〉0. 05）. CRP in the two groups increased significantly after parturition,and IL-6 decreased significantly（ P〈0. 05）. The levels of CRP and IL-6 in the study group were significantly lower than those in the control group,the difference was statistically significant（ P〈0. 05）. CONCLUSION： Dinoprostone suppositories combined with cefuroxime has definite effect on the treatment of preterm premature rupture of membranes,and can increase the rate of vagin

关 键 词：地诺前列酮栓 头孢呋辛 足月胎膜早破 宫内感染 缩宫素 

分 类 号：R72[医药卫生—儿科]