免疫肠内营养支持治疗对重症脑卒中患者营养状况、免疫功能及预后的影响  

Effect of immune enteral nutrition support therapy on nutritional status,immune function and prognosis in patients with severe stroke

作　　者：林丹 肖永红[2] LIN Dan;XIAO Yonghong(Department of Neurology,First People ＇ s Hospital of Tonglu County,Tonglu 311500,CHINA)

机构地区：[1]桐庐县第一人民医院神经内科,浙江311500 [2]浙江大学医学院附属第一医院消化内科

出　　处：《江苏医药》2018年第7期811-814,共4页Jiangsu Medical Journal

基　　金：卫生部部属(管)医疗机构临床学科重点项目(201002021)

摘　　要：目的探讨免疫肠内营养支持治疗对重症脑卒中患者营养状况、免疫功能及预后的影响。方法将100例重症脑卒中患者随机均分为免疫肠内营养支持治疗组(A组)和常规肠内营养支持治疗组(B组),比较两组治疗效果。结果与B组相比,A组治疗后CD8^+水平降低(P<0.05),总蛋白、前清蛋白、白蛋白、血红蛋白、总胆固醇、三酰甘油、IgG、IgM、IgA、CD4^+及CD4^+/CD8^+升高(P<0.05)。A组治疗后GCS评分高于B组[(11.51±0.75)分vs.(10.32±0.82)分](P<0.05),并发症发生率低于B组(42.0%vs.64.0%)(P<0.05)。结论与常规肠内营养比较,对重症脑卒中患者给予免疫肠内营养支持治疗的疗效更好,且能有效提高患者免疫功能,改善预后。Objective To investigate the effect of immune enteral nutrition support therapy on the nutritional status,immune function and prognosis in the patients with severe stroke.Methods A total of 100 patients with severe stroke was equally randomized into two groups.The patients in group A received immune enteral nutrition support therapy and those in group B received conventional enteral nutrition therapy.The clinical outcomes were compared between two groups.Results Compared with group B,the level of CD8~＋was decreased,while the levels of total protein,prealbumin,albumin,hemoglobin,total cholesterol,triacylglycerol,IgG,IgM,IgA,CD4＋and CD4＋/CD8＋were increased after treatment in group A（P〈0.05）.The GCS score after treatment in group A was higher than that in group B [（11.51±0.75）points vs.（10.32±0.82）points]（P〈0.05）,but the incidence of complications in group A was lower than that in group B（42.0% vs.64.0%）（P〈0.05）.Conclusion Compared to conventional enteral nutrition therapy,the immune enteral nutrition support in the treatment of patients with severe stroke has better clinical efficacy with improved immune function and prognosis.

关 键 词：重症脑卒中 免疫肠内营养 

分 类 号：R743[医药卫生—神经病学与精神病学]