硫化氢对尿源性脓毒血症肾组织细胞因子表达的影响分析  

Effect of Hydrogen Sulfide on the Expression of Cytokines in Renal Tissue of Patients with Urinary Sepsis

作　　者：唐亚纯[1] 符浩[1] 郭涛[1] 段斌[1] 王昕禧 陈选才 TANG Ya-chun;FU Hao;GUO Tao(Urinary Surgery,Affiliated Nanhua Hospital,University of South China,Hengyang,Hunan,421002,China)

机构地区：[1]南华大学附属南华医院泌尿外科,湖南衡阳421002

出　　处：《黑龙江医学》2018年第7期642-644,共3页Heilongjiang Medical Journal

摘　　要：目的研究硫化氢对尿源性脓毒血症肾组织细胞因子表达的影响。方法本次研究选取2016年10月2日—2017年10月3日期间在南华大学附属南华医院进行治疗的男性患者80例为研究对象,分为正常组、假手术组、脓毒血症组、硫化氢组,每组患者各20例。将四组研究对象不同时间点的肾功能、TNF-α和IL-10蛋白表达、NF-κB的基因表达水平进行比对。结果术后不同时间点,正常组的肾功能、TNF-α和IL-10蛋白表达、NF-κB的基因表达水平与假手术组数据相差不大(P>0.05);脓毒血症组的肾功能、TNF-α、NF-κB均比其他三组高(P<0.05);硫化氢组的IL-10蛋白表达高于其他三组(P<0.05)。结论硫化氢能够对尿源性脓毒血症肾组织细胞因子表达水平进行有效抑制,从而使尿源性脓毒血症肾损伤情况减轻。Objective To study the effect of hydrogen sulfide on the expression of cytokines in renal tissue of patients with urinary sepsis. Methods 80 male patients who were treated in the hospital from October 2,2016 to October 3,2017 were selected and divided into normal group,sham operation group,sepsis group and hydrogen sulfide group,with 20 cases in each group. The renal function,TNF-alpha and IL-10 protein expression,and the expression level of NF-kappa B gene were compared among the four groups at different time points. Results At different time points after surgery,the difference of renal function,TNF-alpha and IL-10 protein expression and NF-κB gene expression level in normal group is not significant with the sham operation group（ P〈0. 05）.Renal function,TNF-alpha and NF-κB of sepsis group were higher than the other three groups（ P〉0. 05）. Expression of IL-10 protein in hydrogen sulfide group is higher than the other three groups（ P〈0. 05）. Conclusion Hydrogen sulfide can effectively inhibit the expression of cytokines in renal tissue of patients with urinary sepsis,so as to reduce the renal damage of urine derived sepsis.

关 键 词：硫化氢 尿源性脓毒血症 肾组织 细胞因子表达 

分 类 号：R696[医药卫生—泌尿科学]