降钙素原和C反应蛋白在新生儿病理性黄疸中临床意义分析  

Clinical significance of procalcitonin and C reactive protein in neonatal pathological jaundice

作　　者：李微 LI Wei(The Third Affiliated Hospital of Guangdong Medical University,Shunde District Longjiang Hospital,Shunde 528000,Chin)

机构地区：[1]广东医科大学附属第三医院(顺德区龙江医院),528000

出　　处：《中国实用医药》2018年第21期29-31,共3页China Practical Medicine

摘　　要：目的探讨降钙素原和C反应蛋白在新生儿病理性黄疸中的临床意义。方法选取82例病理性黄疸新生儿,根据总胆红素水平分为轻度组(总胆红素水平为221.0~341.9μmol/L,34例)、中度组(总胆红素水平为342.0~427.5μmol/L,29例)和重度组(总胆红素水平>427.5μmol/L,19例),另选同期健康新生儿31例作为对照组。检测四组新生儿的降钙素原和C反应蛋白水平,并给予病理性黄疸患儿相应治疗。比较四组新生儿降钙素原和C反应蛋白水平,并比较中度组与重度组组内治疗前后的降钙素原和C反应蛋白水平差异。结果轻度组、中度组和重度组新生儿的血清降钙素原和C反应蛋白检测水平均明显高于对照组,差异具有统计学意义(P<0.05);重度组血清降钙素原和C反应蛋白检测水平均明显高于轻度组和中度组,差异具有统计学意义(P<0.05);中度组血清降钙素原和C反应蛋白检测水平均明显高于轻度组,差异具有统计学意义(P<0.05)。重度组和中度组治疗后血清降钙素原[(6.97±1.02)、(2.45±0.78)μg/L]和C反应蛋白水平[(8.12±1.79)、(4.65±1.17)mg/L]均明显低于本组治疗前[(11.20±2.04)、(5.01±1.62)μg/L和(17.35±2.39)、(10.11±2.47)mg/L],差异具有统计学意义(P<0.05)。结论降钙素原和C反应蛋白在新生儿病理性黄疸中水平升高,两项指标对新生儿病理性黄疸早期诊断和早期治疗具有重要临床意义。Objective To explore the clinical significance of procalcitonin and C reactive protein in neonatal pathological jaundice. Methods A total of 82 cases of neonatal pathological jaundice were divided into mild group（total bilirubin level was 221.0-341.9 μmol/L, 34 cases）, moderate group（total bilirubin level was 342.0-427.5 μmol/L, 29 cases） and severe group（total bilirubin level was more than 427.5 μmol/L, 19 cases） according to the total bilirubin level. At the same time, 31 healthy newborns were selected as the control group. The levels of procalcitonin and C reactive protein were detected in four groups, and children with pathological jaundice were given corresponding treatment. The levels of procalcitonin and C reactive protein were compred in four groups, the differences of procalcitonin and C reactive protein levels between the moderate group and the severe group were compared before and after treatment. Results The detection levels of serum procalcitonin and C reactive protein in the mild group, moderate group and severe group were significantly higher than those in the control group, and the differences were statistically significant（P〈0.05）. The detection levels of serum procalcitonin and C reactive protein in the severe group were significantly higher than those in the mild group and the moderate group, the differences were statistically significant（P〈0.05）. The detection levels of serum procalcitonin and C reactive protein in the moderate group were significantly higher than those in the mild group, the differences were statistically significant（P〈0.05）. The detection level of serum procalcitonin in the severe group and the moderate group after treatment were（6.97±1.02） μg/L and（2.45±0.78） μg/L respectively, which were significantly lower than（11.20±2.04） μg/L and（5.01±1.62） μg/L before treatment in same group, the differences were statistically significant（P〈0.05）. The detection levels of C reactive protein in the severe group and the modera

关 键 词：新生儿 病理性黄疸 降钙素原 C反应蛋白 临床意义 

分 类 号：R722.17[医药卫生—儿科]