不同剂量阿托伐他汀治疗糖尿病心肌病患者的疗效及其对血糖、血脂和不良心脏事件的影响  

Efficiency of different doses of atorvastatin in the treatment of patients with diabetic cardiomyopathy and their effects on blood glucose,blood lipid and adverse cardiac events

作　　者：杜剑 DU Jian(Department of Cardiovascular Medicine,Longxian People＇s Hospital,Longxian,Shaanxi,721200)

机构地区：[1]陕西省陇县人民医院心血管内科,陕西陇县721200

出　　处：《实用临床医药杂志》2018年第13期27-30,共4页Journal of Clinical Medicine in Practice

摘　　要：目的分析不同剂量的阿托伐他汀对糖尿病并发心肌病患者心脏舒张功能不全的疗效,血糖、血脂代谢以及不良心脏事件的影响。方法选取糖尿病心肌病患者68例,随机分为试验组和对照组各34例。对照组给予常规剂量阿托伐他汀治疗,试验组给予加倍剂量的阿托伐他汀治疗,比较2组患者治疗前后心脏舒张功能,血糖、血脂代谢变化以及不良心脏事件的发生比例。结果治疗前,2组患者的心脏舒张功能指标比较,差异无统计学意义(P>0.05);治疗后,2组患者的心脏舒张功能显著改善,且试验组患者的心脏舒张功能显著优于对照组(P<0.05);治疗前,2组患者的血糖、血脂代谢水平差异无统计学意义(P>0.05);治疗后,2组患者的血糖、血脂代谢指标水平均改善,且试验组改善程度显著优于对照组(P<0.05);2组不良心脏事件发生率无显著差异(P>0.05)。结论基于糖尿病并发心肌病患者的心脏舒张功能及血脂代谢变化,加倍剂量给予阿托伐他汀治疗效果更佳。Objective To explore the effects of different doses of atorvastatin on the clinical efficacy,blood glucose,blood lipid metabolism,and adverse cardiac events in patients with diabetes mellitus complicated with cardiomyopathy. Methods Totally 68 patients with diabetic cardiomyopathy were selected and randomly divided into experimental group and control group,34 cases in each group. The control group was given conventional dose of atorvastatin,and the experimental group was given a double dose of atorvastatin. The changes of diastolic function,blood glucose,dyslipidemia and the incidence of adverse cardiac events were compared before and after treatment between the two groups. Results There was no significant difference in diastolic function between the two groups before treatment（ P〉0. 05）. After treatment,the diastolic function in both groups significantly improved,and the diastolic function in the experimental group was significantly better than that in the control group（ P〈0. 05）. There was no significant difference in blood glucose and lipid metabolism between the two groups before treatment（ P〉0. 05）. After treatment,the blood glucose and blood lipid metabolism indexes in both groups significantly improved,and the improvement degree of the experimental group was significantly better than the control group（ P〈0. 05）. After treatment,the incidence rate of adverse cardiac events in the experimental group was significantly lower than that in the control group（ P〈0. 05）. Conclusion Cardiac diastolic function and lipid metabolism change in patients with diabetes mellitus complicated with cardiomyopathy. The double dose of atorvastatin is more effective.

关 键 词：阿托伐他汀 糖尿病 心肌病 心脏舒张功能不全 血脂 

分 类 号：R587.2[医药卫生—内分泌]