细菌性肺炎患儿病原菌分布及炎症因子表达情况检测分析  

Analysis of distribution of pathogens and expression of inflammatory factors in children with bacterial pneumonia

作　　者：宋谦 赵淑珍 杨靖 SONG Qian;ZHAO Shuzhen;YANG Jing(Department of Clinical Laboratory,Urumqi Hospital of Traditional Chinese Medicine,Urumqi,Xinjiang 830099,Chin)

机构地区：[1]新疆乌鲁木齐市中医医院检验科,乌鲁木齐830099

出　　处：《国际检验医学杂志》2018年第14期1712-1714,1717,共4页International Journal of Laboratory Medicine

基　　金：新疆维吾尔自治区科技攻关(含重大专项)和重点项目计划(No200733146)

摘　　要：目的分析细菌性肺炎患儿病原菌分布及炎症因子表达情况。方法选择该院2015年4月至2017年4月收治的96例细菌性肺炎患儿,选取96例同期体检健康儿童作为对照组。分析细菌性肺炎患儿病原菌分布情况,选用酶联免疫法测定并比较细菌性肺炎组和对照组降钙素原(PCT)、超敏C反应蛋白(hsCRP)、白细胞介素(IL)-6、IL-8、肿瘤坏死因子-α(TNF-α)水平。结果 96例细菌性肺炎患儿病原菌中革兰阴性菌为53.12%(51/96)、革兰阳性菌为43.75%(42/96),其他菌株为3.13%(3/96)。细菌性肺炎组hs-CRP、IL-6、IL-8、TNF-α水平均显著高于对照组,差异有统计学意义(P<0.05)。细菌性肺炎组治疗后hs-CRP、IL-6、IL-8、TNF-α水平均明显低于治疗前,差异有统计学意义(P<0.05)。结论细菌性肺炎患儿病原菌分布以革兰阴性菌为主,炎症因子表达明显上调,有利于疾病诊断,临床用药需掌握病原菌的分布及炎症因子特点,以提高治疗可行性。Objective To analyze the distribution of pathogenic bacteria and expression of inflammatory factors in children with bacterial pneumonia.Methods 96 cases of bacterial pneumonia admitted in the hospital from April 2015 to April 2017 were selected,and 96 healthy children was selected as control group.Pathogen distribution in children with bacterial pneumonia was analyzed,enzyme-linked immune method was used to detect the procalcitonin（PCT）,hypersensitive c-reactive protein（hs-CRP）and interleukin 6（IL-6）,interleukin（IL-8）,tumor necrosis factor-α（TNF-α）levels in bacterial pneumonia group and the control group and the levels between the two groups were compared.Results Gram negative bacteria strains found in 96 children with bacterial pneumonia was 53.12%（51/96）,gram-positive bacteria was 43.75%（42/96）,and the other strains was 3.13%（3/96）.The levels of PCT,hs-CRP,IL-6,IL-8 and TN-αin bacterial pneumonia group was significantly higher than those in the control group,and differences were statistically significant（P〈0.05）.The levels of PCT,hs-CRP,IL-6,IL-8 and TNF-αin the bacterial pneumonia group after treatment were significantly lower than those before treatment,and differences were statistically significant（P〈0.05）.Conclusion Pathogens in children with bacterial pneumonia were mainly Gram-negative bacteria,inflammatory factor expression is significantly upregulated,which is conducive to the diagnosis of the disease,the distribution of pathogenic bacteria and the characteristics of inflammatory factors need to be taken into consideration for clinical medication,so as to improve the feasibility of treatment.

关 键 词：小儿细菌性肺炎 病原菌分布 炎症因子 

分 类 号：R446.5[医药卫生—诊断学]