血清IgA/C3比值对IgA肾病辅助诊断的应用价值研究  

Study on application value of serum IgA/C3 ratio in assistant diagnosis of IgA nephropathy

作　　者：刘传江[1] L IU Chuanjiang(Department of Clinical Laboratory,the People＇s Hospital of Macheng,Macheng,Hubei 438300,Chin)

机构地区：[1]湖北省麻城市人民医院医学检验科,湖北麻城438300

出　　处：《国际检验医学杂志》2018年第14期1749-1752,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨血清IgA/C3比值对IgA肾病辅助诊断的应用价值。方法选择该院2012年1月至2016年12月经肾脏活检确诊的原发性IgA肾病患者80例、其他肾小球疾病患者120例以及同期健康体检者100例作为研究对象。分别检测血清中的IgA和C3水平,计算血清IgA/C3比值对IgA肾病诊断的敏感度和特异度,并分析其与患者临床特征的相关性。结果 IgA肾病患者血清IgA/C3比值显著高于非IgA肾病患者和健康体检者,差异有统计学意义(P<0.05),诊断IgA肾病的敏感度为79.41%,特异度为68.36%,ROC曲线下面积为0.758,截断点为2.28;肾脏活检组织病理IgA免疫荧光染色越强,IgA/C3比值越高,差异有统计学意义(P<0.05),但IgA/C3比值与IgA肾病患者的组织病理学分级之间无明显相关性,差异无统计学意义(P>0.05)。结论血清IgA/C3比值与IgA肾病患者的病理改变程度和病情相关,可作为临床诊断的重要辅助手段,具有一定的应用价值。Objective To explore the application value of serum IgA/C3 ratio in auxiliary diagnosis of IgA nephropathy.Methods From January 2012 to December 2016,80 cases of primary IgA nephropathy diagnosed by renal biopsy,120 cases of other glomerular diseases and 100 healthy people who underwent physical examination were selected as the research subjects.The serum levels of IgA and C3 were detected,and the sensitivity and specificity of serum IgA/C3 ratio in the diagnosis of IgA nephropathy were calculated,and the correlation with the clinical features of the patients was analyzed.Results The serum IgA/C3 ratio of patients with IgA nephropathy was significantly higher than that of non IgA nephropathy patients and healthy persons,and difference was statistically significant（P〈0.05）.The sensitivity of the diagnosis of IgA nephropathy was79.41%,the specificity was 68.36%,the area under the ROC curve was 0.758,and the cutoff value was 2.28;the more obvious the IgA immunofluorescence staining of the IgA/C3 ratio in renal biopsy tissue was,the higher the IgA/C3 ratio was,and difference was statistically significant（P〈0.05）.But there was no significant correlation between the IgA/C3 ratio and the histopathological classification of patients with IgA nephropathy,and the difference was not statistically significant（P〉0.05）.Conclusion The serum IgA/C3 ratio is related to the pathological changes and condition of patients with IgA nephropathy,which can be used as an important auxiliary means for clinical diagnosis and has certain application value.

关 键 词：IGA肾病 血清IgA/C3比值 辅助诊断 

分 类 号：R446.1[医药卫生—诊断学]