MEBT/MEBO对WagnerⅡ级糖尿病足溃疡病人28d创面愈合率及周围神经病变的影响研究  

The influence of MEBT/MEBO on the 28th day healing rate and peripheral neuropathy in patients with Wagner grade Ⅱ diabetic foot ulcers

作　　者：符黄德[1] 舒清峰 唐乾利[2] 葛斌[2] 李利青[2,3] 王澍 黄庆[1] 何明杰[1] 杨大伟[1] Fu Huangde;Shu Qingfeng;Tang Qianli;Ge Bin;Li Liqing;Wang Shu;Huang Qing;He Mingjie;Yang Dawei(Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Youjiang Medical Uniuersity for Nationalities,Baise 533000,Guangxi,China;Graduate Sckool,Hunan University of Chinese Medicine,Changsha 410208,Hunan,China)

机构地区：[1]右江民族医学院附属医院,广西百色533000 [2]右江民族医学院,广西百色533000 [3]湖南中医药大学研究生院,湖南长沙410208

出　　处：《右江民族医学院学报》2018年第3期209-212,共4页Journal of Youjiang Medical University for Nationalities

基　　金：2015年国家自然科学基金项目(81560776)

摘　　要：目的观察烧伤湿性医疗技术(Moist Exposed Burn Therapy,MEBT)/湿润烧伤膏(Moist Exposed Burn Ointment,MEBO)(MEBT/MEBO)对WagnerⅡ级糖尿病足溃疡病人治疗28d时创面愈合率及周围神经病变的影响。方法选取右江民族医学院附属医院2013年10月—2016年6月间治疗的WagnerⅡ级糖尿病足伴有2型糖尿病的患者52例,随机分为美宝组(26例)和贝复新组(26例),前者予外用美宝湿润烧伤膏治疗,后者予外用重组牛碱性成纤维细胞生长因子凝胶治疗,对比两组患者治疗28d时的创面愈合率,以及对比入院时及治疗14d、28d的密歇根神经病变筛查量表(MNSI)评分。结果美宝组与贝复新组28d的创面愈合率差异无统计学意义(P>0.05);两组在入院时、治疗14d和28d的MNSI评分逐渐降低,组内三个时间点MNSI评分差异有统计学意义(P<0.05),组间差异无统计学意义(P>0.05)。结论 MEBT/MEBO能促进WagnerⅡ级糖尿病足溃疡创面的愈合及改善糖尿病周围神经病变的症状。Objective To observe the influence of Moist Exposed Burn Therapy（MEBT）/Moist Exposed Burn Ointment（MEBO）on the 28 th day healing rate and peripheral neuropathy in patients with Wagner gradeⅡ diabetic foot ulcers. Methods Fifty-two patients who were diagnosed with type 2 diabetes combined with Wagner gradeⅡ diabetic foot and were treated at the Affiliated Hospital of Youjiang Medical University for Nationalities from October 2013 to June 2016,26 out of the 52 cases were randomly allocated to a MEBO group and another 26 cases to a recombinant bovine basic fibroblast growth factor（rb-bFGF）group.Patients in MEBO group were treated with MEBT/MEBO,while patients in rb-bFGF group were treated with rb-bFGF.Patients in each group received the assessments of the healing rate of the wounds at the 28 th day of treatment and the assessments of Michigan Neuropathy Screening Instrument（MNSI）at the time of hospital admission,at the 14 th day of treatment and the 28 th day of treatment,respectively.The results were compared between the two groups. Results Comparison of the 28 th day healing rate in MEBO group with that of the rb-bFGF group yielded that there was no statistically significant difference（P〈0.05）.MNSI scores of the two groups showed a gradually falling trend at the three time points,i.e,the day of hospital admission,the 14 th day of treatment and the 28 th day of treatment.At the three above-mentioned time points,every inner-group comparison of MNSI score showed statistical difference（P〈0.05）and every inter-group comparison of MNSI score showed no statistical difference（P〉0.05）. Conclusion MEBT/MEBO can promote the wound healing of Wagner gradeⅡ diabetic foot ulcers and improve the symptoms of diabetic peripheral neuropathy.

关 键 词：MEBT/MEBO 糖尿病足 周围神经病变 

分 类 号：R587.29[医药卫生—内分泌]