血清及腹腔液中VEGF、MMP-2、MMP-9水平在子宫内膜异位症中的诊断价值  

Detection of serum and peritoneal fluid VEGF,MMP-2,MMP-9 Levels in the diagnosis of endometriosis

作　　者：孟宪宁 李红霞[1] 吴亚男 霍志平[1] 郝媛媛[1] 王宏利[1] MENG Xianning;LI Hongxia;WU Yanan;HUO Zhiping;HAO Yuanyuan;FANG Hongli(Department of Obstetrics and Gynecology,Central Hospital of China Petroleum and Natural Gas Group Corporation,Hebei,Langfang 065000,Chin)

机构地区：[1]中国石油天然气集团公司中心医院妇产科,河北廊坊065000

出　　处：《疑难病杂志》2018年第8期825-827,832,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省廊坊市科技创新项目(2017013145)

摘　　要：目的探讨检测血清及腹腔液中血管内皮生长因子(VEGF)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)水平对诊断子宫内膜异位症的价值。方法选取2016年2月一2017年11月于中国石油天然气集团公司中心医院妇产科经手术等检查证实为子宫内膜异位症的100例患者作为观察组,另选取同期治疗的100例非子宫内膜异位症患者作为对照组。分别检测2组患者血清及腹腔液中VEGF、MMP-2、MMP-9水平并进行比较。结果观察组患者血清中VEGF、MMP-2、MMP-9水平明显高于对照组(t=17.038、11.945、17.838,P均<0.01);观察组患者腹腔液中VEGF、MMP-2、MMP-9水平明显高于对照组(t=22.364、15.621、15.556,均<0.01)。观察组中,Ⅲ～Ⅳ期患者血清中VEGF、MMP-2、MMP-9水平明显高于Ⅰ～Ⅱ期(t=9.349、10.395、16.535,P均<0.01);Ⅲ～Ⅳ期患者腹腔液中VEGF、MMP-2、IMMP-9水平明显高于Ⅰ～Ⅱ期(t=9.772、13.853、13.347,P均<0.01)。血清中VEGF、MMP-2、MMP-9水平与子宫内膜异位症分期呈正相关性(r=0.975、0.768、0.761,P均<0.05);腹腔液中VEGF、MMP-2、MMP-9水平与子宫内膜异位症分期亦呈正相关性(r=0.911、0.772、0.767 P均<0.05)。结论检测子宫内膜异位症患者血清和腹腔液中VEGF、MMP-2、MMP-9水平可有助于诊断和评估患者病情,为临床治疗方案制定提供指导价值。Objective To investigate the significance of detecting serum levels of vascular endothelial growth factor（VEGF）, matrix metalloproteinase 2（MMP-2） and matrix metalloproteinase 9（ MMP-9） in the diagnosis of endometriosis.Methods Selected in our hospital after surgery and other tests confirmed 100 cases of endometriosis as the study observation group, the other selected the same period in our hospital for treatment of 100 cases of non-endometriosis patients as the study control group. The levels of VEGF, MMP-2 and MMP-9 in serum and peritoneal fluid of the two groups were detected. Results The serum levels of VEGF, MMP-2 and MMP-9 in the observation group were（236. 5 ±59. 8） ng/L,（195. 8 ±52. 2） μg/L,（232. 5 ±43. 8） μg/L, which were significantly higher than those in the control group（118. 7 ±34. 7） ng/L,（ 124.7 ±28.6） μ/L,（138.7 ±29.1）μg/L（t= 17.038,t= 11.945, t= 17.838, P〈0.01）; VEGF,MMP2, MMP9 in the peritoneal fluid of the observation group were（861.2 ±258. 7） ng/L,（44. 9 ± 14. 1） μg/L, and（55. 1 ±18.8） μg/L, respectively,which were significantly higher than those of the control group（269. 8 ±54. 8） μg/L,（18. 6）. ± 9. 2） μg/L,（24.0 ± 6. 8） μg/L（t = 22. 364,t= 15. 621,t= 15. 556,P〈0. 01）. In the observation group,the serum levels of VEGF,MMP-2, and MMP-9 were significantly higher in stage Ⅲ,Ⅳ patients than in stage Ⅰ, Ⅱ（t =9. 349, t = 10. 395, t= 16.535, P 0.05）; in the observation group, stage Ⅲ,Ⅳ＇s VEGF, MMP-2, and MMP-9 in patients＇ peritoneal fluid were significantly higher than those in stage I to II（t =9. 772, t=13. 853, t=13. 347, P 0. 05）. Conclusion Detection of VEGF, MMP-2, MMP-9 levels in serum and peritoneal fluid of patients with endometriosis can help clinicians to diagnose and assess the patients condition, and provide guidance value for the development of clinical treatment plan.

关 键 词：子宫内膜异位症 血管内皮生长因子 基质金属蛋白酶-2 基质金属蛋白酶-9 

分 类 号：R711.71[医药卫生—妇产科学]