母婴Rh血型不合胎儿和新生儿溶血病相关临床问题研究  

Research status on clinical problems of rhesus maternal-fetal blood group incompatibility hemolytic disease of fetus and newborn

作　　者：敖雪 谭世桥 余海燕 Ao Xue;Tan Shiqiao;Yu Haiyan(Department of Obstetrics and Gynecology,Key Laboratory of Birth Defects and Related Diseases of Women and Children（Sichuan University）,Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2018年第3期249-255,共7页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：四川省人力资源和社会保障厅学术和技术带头人培养支持经费项目([2016]183-31);成都市科技局基金资助项目(2014-HM01-00039-SF)

摘　　要：母婴Rh血型不合胎儿和新生儿溶血病(Rh-HDFN),是胎儿或新生儿同种被动免疫溶血性贫血最常见原因之一。Rh-HDFN导致的胎儿或新生儿病情危重,可引起胎儿严重贫血、水肿、心力衰竭、死胎,或导致新生儿核黄疸及死亡等,而幸存Rh-HDFN新生儿,则可能遗留智力发育不全、运动功能障碍等神经系统后遗症。临床对于Rh-HDFN的早期诊断、及时治疗与胎儿及新生儿预后的关系紧密相关。Rh-HDFN的产前预防,越来越受到产科临床的关注。笔者拟针对Rh-HDFN临床相关问题的最新研究进展进行阐述。Rhesus maternal-fetal blood group incompatibility hemolytic disease of fetus and newborn（Rh-HDFN）is one of the most common causes of passive immune hemolytic anemia in fetuses or neonates.Rh-HDFN is critically ill,which can cause severe fetal anemia,edema,heart failure,stillbirth and neonatal kernicterus,death.Survival newborns with Rh-HDFN may suffer mental retardation,motor disorders and other neurological sequelae.Early diagnosis of Rh-HDFN and timely treatment are closely related to the prognosis of fetus and newborn,which has attracted more and more clinical attention.This article focuses on related clinical issues and the latest research advance in Rh-HDFN.

关 键 词：RH-HR血型系统 贫血 溶血性 自身免疫性 免疫法 被动 血型不合 幼红细胞增多症 胎儿 一级预防 治疗结果 孕妇 

分 类 号：R722.18[医药卫生—儿科]