PKRP对BPH患者前列腺功能与血清前列腺特异抗原水平的影响  

Effect of PKRP on prostate function and serum prostate specific antigen level in patients with BPH

作　　者：刘龙强[1] 白如玉[1] 汪峰[2] 刘安[1] 何海宝[1] LIU Long-qiang;BAI Ru-yu;WANG Feng;LIU An;HE Hai-bao(Department of Uropoiesis Surgical,Yan＇an People＇s Hospital,Shaanxi Province,Yan＇an 716000,China;Department of Uropoiesis Surgical,Yan＇an University Affiliated Hospital,Shaanxi Province,Yan＇an 716000,China)

机构地区：[1]陕西省延安市人民医院泌尿外科,陕西延安716000 [2]延安大学附属医院泌尿外科,陕西延安716000

出　　处：《河北医科大学学报》2018年第8期921-924,928,共5页Journal of Hebei Medical University

摘　　要：目的探讨经尿道双极等离子电切术(plasma kinetic resection of prostate,PKRP)对良性前列腺增生(benign prostatic hyperplasia,BPH)患者前列腺功能与血清前列腺特异抗原水平的影响。方法选择良性前列腺增生患者120例,随机分为试验组和对照组各60例。试验组行PKRP,对照组行传统经尿道前列腺切除术(transurethral resection of prostate,TURP)。对比2组治疗前后尿道功能和性功能:尿道功能包括最大尿流率(maximum urinary flow rate,Qmax)、剩余尿量、最大膀胱容量和排尿开始时膀胱压;性功能包括国际勃起功能指数-5(international index of erectile function-5,IIEF-5)和逆行射精人数比例。比较治疗前和治疗后不同时间点2组血清前列腺特异抗原(prostate specific antigen,PSA)水平。结果治疗后试验组Qmax显著大于对照组,剩余尿量和排尿开始时膀胱压显著低于对照组(P<0.05)。治疗后试验组IIEF-5得分显著高于对照组,勃起功能障碍例数和逆行射精例数显著少于对照组(P<0.05)。治疗后2组PSA呈先升高后降低的趋势,观察组低于对照组,2组在组间、时点间,组间·时点间交互作用差异均有统计学意义(P<0.05)。结论 PKRP可有效提高BPH患者术后尿道功能和性功能,且术后28d患者PSA水平可基本恢复正常,值得临床推广。Objective To explore the effect of plasma kinetic resection of prostate（PKRP）on prostate function and serum prostate specific antigen level in patients with benign prostatic hyperplasia（BPH）.Methods The 120 patients with BPH were selected and randomly divided into experimental group and control group.The experimental group was performed transurethral plasma kinetic resection of prostate,while the control group was treated with transurethral resection of prostate.The urethral function and sexual function were compared between the two groups before and after treatment：Urethral function included maximum urinary flow rate（Qmax）,residual urine volume,maximum bladder volume and bladder pressure at the beginning of voiding;Sexual function included the International Index of Erectile Function-5（IIEF-5）and the proportion of people with retrograde ejaculation.Serum prostate specific antigen（PSA）levels were compared between the two groups before and after treatment.Results After treatment,the Qmaxin the experimental group was significantly higher than that in the control group,the residual urine volume and urinary bladder pressure at the beginning of urination were significantly lower than those in the control group（P〈0.05）.After treatment,the IIEF-5 score of the experimental group was significantly higher than that of the control group,the number of erectile dysfunction and the number of retrograde ejaculation was significantly lower than that of the control group（P〈0.05）.After treatment,the PSA of two groups was first increased and then decreased.The observation group was lower than the control group.The differences between the two groups were statistically significant（P〈0.05）.Conclusion PKRP can effectively improve the postoperative urethral function and sexual function in patients with BPH,and 28 days after operation,the level of PSA in patients returned to normal.It is worthy of clinical application.

关 键 词：前列腺增生 经尿道前列腺切除术 前列腺特异抗原 

分 类 号：R697.32[医药卫生—泌尿科学]