SD雄性大鼠不同年龄段相关性激素水平  

Associated sex hormone levels in different age of SD male rats

作　　者：张国飞[1] 吴越[1] 邓玮[1] 陈安龙[1] 丁兴旺 史京[1] ZHANG Guo-fei;WU Yue;DENG Wei;CHEN An-long;DING Xing-wang;SHI Jing(Urology Surgery Department,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,Chin)

机构地区：[1]新疆医科大学第六附属医院泌尿外科,新疆乌鲁木齐830002

出　　处：《临床医学研究与实践》2018年第23期4-5,共2页Clinical Research and Practice

基　　金：新疆维吾尔自治区自然科学基金(No.2015211C183)

摘　　要：目的检测SD雄性大鼠不同月龄相关性激素水平变化及规律,探讨影响性激素的因素,为今后雄性激素相关实验提供正常参考值。方法取20只1月龄雄性SD大鼠(体重80～121 g),相同饲养条件下,每5只1笼饲养,所有大鼠均从1月龄(幼年)一直养到实验结束。分别在1、4、24月龄检测20只雄性SD大鼠的促卵泡刺激素(FSH)、促黄体生成素(LH)、睾酮(T)水平,每只均测定2次,比较1、4、24月龄大鼠的性激素水平。结果经检测,1月龄(幼年)、4月龄(成年)、24月龄(老年)SD雄性大鼠的血清FSH、T水平比较,差异有统计学意义(P<0.05);1月龄(幼年)、4月龄(成年)、24月龄(老年)SD雄性大鼠的血清LH水平比较,差异无统计学意义(P>0.05)。结论随着SD大鼠月龄的增加,FSH水平逐渐降低,LH处于低水平且变化不明显,T水平随着年龄的增长先由低逐渐升高,进入成年期后逐渐降低。Objective To detect the changes and regularity of sex hormones in SD male rats at different ages, and to explore the factors affecting sex hormones, and provides normal reference values for male hormone related experiments in the future. Methods Twenty male SD rats of 1 month old were selected（body weight 80-121 g）, every 5 rats were kept in one cage under the same feeding conditions, and all rats were raised from 1 month old（young age） to the end of the experiment. The follicle stimulating hormone（FSH）, luteinizing hormone（LH） and testosterone（T） levels of 20 SD rats were detected at 1, 4 and 24 months, each data was measured 2 times, and the levels of sex hormones of rats at 1, 4 and 24 months were compared. Results The levels of serum FSH and T in the SD male rats of 1 month old（young）, 4 months old（adult） and 24 months old（old） were significantly different after detection（P 0.05）. There were no significant differences in the levels of serum LH between the SD male rats of 1 month old（young）, 4 months old（adult） and 24 months old（old）（P0.05）. Conclusion With the increase of the age of SD rats, the level of FSH gradually decreased, LH was at a low level and the change was not obvious, and the level of T increased gradually from low to high and gradually decreased after entering adulthood.

关 键 词：SD雄性大鼠 促卵泡刺激素(FSH) 促黄体生成素(LH) 睾酮(T) 

分 类 号：R332[医药卫生—人体生理学]