普瑞巴林治疗急性期带状疱疹的临床疗效  

Clinical Effect of Pregabalin on Acute Herpes Zoster

作　　者：张峰[1] 王玉玲[1] 袁景桃[1] 李俊杰[1] ZHANG Feng;WANG Yu-ling;YUAN Jing-tao;LI Jun-jie(Department of Dermatology,Dongguan People＇s Hospitol,Dongguan 523059,Chin)

机构地区：[1]东莞市人民医院皮肤科,广东东莞523059

出　　处：《实用临床医学（江西）》2018年第6期26-28,69,共4页Practical Clinical Medicine

摘　　要：目的探讨普瑞巴林治疗带状疱疹急性期神经痛的有效性及其对后遗神经痛的影响。方法将106例带状疱疹急性期患者按治疗方法不同分为3组:对照组24例给予泛昔洛韦、维生素B1、甲钴胺等综合治疗;治疗Ⅰ组42例、治疗Ⅱ组40例在对照组治疗基础上给予普瑞巴林治疗,治疗Ⅰ组第1天早、晚各75 mg,第2天早、晚各150mg,治疗Ⅱ组从第1天开始即早、晚各服用150mg,3组疗程均为4周。比较2组的临床疗效与治疗期间不良反应发生情况,采用视觉模拟评分法(VAS)、阿森斯失眠量表(AIS)评价2组治疗前后疼痛程度及睡眠质量改善情况,治疗后随访3个月,观察2组后遗神经痛的发生率。结果治疗Ⅰ组、Ⅱ组治疗总有效率均显著高于对照组(P<0.05),治疗Ⅰ组与治疗Ⅱ组间比较差异无统计学意义(P>0.05)。3组患者治疗后VAS、AIS评分均较治疗前显著降低(P<0.05或P<0.01),且治疗Ⅰ组、Ⅱ组明显低于对照组治疗后(P<0.05),而治疗Ⅰ组、Ⅱ组比较差异无统计学意义(P>0.05)。治疗Ⅰ组、Ⅱ组后遗神经痛发生率均显著低于对照组(P<0.05),治疗Ⅰ组、Ⅱ组比较差异无统计学意义(P>0.05)。结论普瑞巴林治疗带状疱疹急性期具有镇痛效果好,起效快,安全可靠等优点,能改善患者疼痛的严重程度和睡眠质量,避免发生后遗神经痛的并发症;且不同加量方法不影响其临床疗效。Objective To investigate the effect of pregabalin on acute herpetic neuralgia and postherpetic neuralgia in patients with herpes zoster.Methods A total 106 patients with acute herpes zoster were divided into control group（n=24）,treatment group Ⅰ（n=42）and treatment group Ⅱ（n=40）.All patients were given comprehensive treatment with famciclovir,vitamin B1 and mecobalamin.In addition,the treatment group Ⅰ was treated with pregabalin 75 mg on the first day and 150 mg from the second day twice daily in the morning and evening.However,the treatment group Ⅱreceived pregabalin 150 mg from the first day twice daily in the morning and evening.The course of treatment was 4 weeks.Clinical efficacies and adverse reactions were compared among the three groups.The pain degree and sleep quality were evaluated using Visual Analogue Scale（VAS）and Athens Insomnia Scale（AIS）,respectively.The incidence of postherpetic neuralgia was measured after follow-up for 3 months.Results Compared with control group,the total effective rate increased and the incidence of postherpetic neuralgia reduced in treatment groupsⅠ andⅡ（P〈0.05）.The scores of VAS and AIS decreased in all the three groups after treatment,and the decrease in treatment groups was more obvious than that in control group（P〈0.05 or P〈0.01）.There were no significant differences in the total effective rate,VAS score,AIS score and incidence of postherpetic neuralgia between treatment groupⅠand treatment groupⅡ（P〉0.05）.Conclusion Pregabalin treatment can effectively,quickly,safely and reliably improve pain severity and sleep quality,and avoid complications of postherpetic neuralgia.Different dose regimens of pregabalin have no effect on the clinical efficacy.

关 键 词：普瑞巴林 带状疱疹 急性期 神经痛 有效性 安全性 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]