Synthesis of the Intermediate for Prothioconazole  

作　　者：Wang Tao 

机构地区：[1]Luohe Vocational Technology College, Luohe 462000, China

出　　处：《Plant Diseases and Pests》2018年第2期33-36,共4页植物病虫害研究（英文版）

基　　金：Supported by National Natural Science Foundation of China(30870109)

摘　　要：[Objective] The paper was to study the synthesis technology of the intermediate for prothioconazole： 1-chloro-1-chloroacetyl-cyclopropane. [Method] With 2-acetylbutyrolactone as the raw material, 3,5-dichloro-2-pentanone was synthesized by chlorination and hydrolysis, and1-chloro-1-chloroacetyl-cyclopropane was synthesized by further cyclization and chlorination. [Result] The optimized synthetic process was determined by optimizing reaction conditions of each step. The overall yield of four-step reaction was 76.7%, and the product was verified by1 H NMR and13 C NMR. [Conclusion] The chlorinated product of 2-acetylbutyrolactone was directly hydrolyzed in acid solution without separation, and the final product was obtained by chlorination of cyclization product in the presence of special catalyst methanol. The whole process was smooth and the yield of the reaction was high, with high value for industrial application.[Objective] The paper was to study the synthesis technology of the intermediate for prothioconazole： 1-chloro-1-chloroacetyl-cyclopropane. [Method] With 2-acetylbutyrolactone as the raw material, 3,5-dichloro-2-pentanone was synthesized by chlorination and hydrolysis, and1-chloro-1-chloroacetyl-cyclopropane was synthesized by further cyclization and chlorination. [Result] The optimized synthetic process was determined by optimizing reaction conditions of each step. The overall yield of four-step reaction was 76.7%, and the product was verified by1 H NMR and13 C NMR. [Conclusion] The chlorinated product of 2-acetylbutyrolactone was directly hydrolyzed in acid solution without separation, and the final product was obtained by chlorination of cyclization product in the presence of special catalyst methanol. The whole process was smooth and the yield of the reaction was high, with high value for industrial application.

关 键 词：2-Acetylbutyrolactone Sulfuryl chloride METHANOL CATALYST 

分 类 号：S1[农业科学—农业基础科学]