一种无线充电、无线通信的植入式癫痫信号检测器  

An implantable epileptic signal detector with wireless charging and wireless communication

作　　者：钱尼信 朱云帆 时欢 钟彬彬 吴金利 汪捷 李效龙[1] Qian Nixin;Zhu Yunfan;Shi Huan;Zhong Binbin;Wu Jinli;Wang Jie;Li Xiaolong(School of Electronics and Information,Jiangsu University of Science and Technology,Zhenjiang 212003,China)

机构地区：[1]江苏科技大学电子与信息学院,江苏镇江212003

出　　处：《电子技术应用》2018年第7期76-80,共5页Application of Electronic Technique

基　　金：国家自然科学基金面上项目(61671221)

摘　　要：提出了一种无线癫痫信号检测器,主要由记录电极、癫痫信号提取和放大模块(包括斩波放大器和滤波器)、射频能量收集器(RFEH)、蓝牙模块和癫痫信号检测算法等组成,用于构建闭环神经刺激器。设计了一种由多级"零漂移"同相放大器组成的斩波放大器、用于分离局部场电位(LFP)和棘波(Spikes)的低通滤波器(200 Hz)和带通滤波器(300 Hz^5 000 Hz),以及由单通路Villard倍压整流电路构成的RFEH(为系统供电)。采用海岸线参数法来检测癫痫信号的发作。测试结果表明,斩波放大器的输入漂移电压为1μV,LFP和Spikes的增益分别为40 d B和100 dB。当发射功率为25 dBm@2.45 GHz、测试距离为2 cm,在无负载和负载为1 kΩ时,RFEH的输出电压分别为5.6 V和2.6 V,带载时能量转换效率为2%。海岸线参数算法的准确率为91.1%。An epileptic signal detector with wireless charging and wireless communication is proposed in this work, which can be used to build a closed-loop neurostimulator. The detector consists of two recording electrodes, an epilepsy signal extraction and amplification module（including a chopper amplifier and two filters）, a radio frequency energy harvester（RFEH）, a blue-tooth module and an epileptic signal detection algorithm. The chopper amplifier is realized by a multistage in-phase amplifier with the‘zero drift ＇ operational amplifier. The RFEH, which is the power supply of the system, is designed with a single channel Villard voltage doubler. The coastline parameters are employed to detect the seizure of the epilepsy. Measurement results show that the input volt-age drift of the chopper amplifier is 1 μV. The gain of the local field potentials（LFP） and spikes are 40 dB and 100 dB. When the transmission power is 20 dBm@2. 45 GHz, the distance between the transmitter and receiver is 2 cm, and with and without 1 kΩload, the regulated voltage of the RFEH are 2. 6 V and 5. 6 V, and the energy conversion efficiency is 2 % when with the load.The detection accuracy of the coastline parameter method is 91. 1 %.

关 键 词：斩波放大器 癫痫检测算法 癫痫脑电信号 射频能量收集器 局部场电位 棘波 

分 类 号：TN709[电子电信—电路与系统] Q819[生物学—生物工程]