能谱CT成像定量评估Budd-Chiari综合征患者肝功能  

Spectral CT quantitative parameters in evaluation of liver function of patients with Budd-Chiari syndrome

作　　者：苏蕾[1] 梁盼[1] 常丽阳 胡丽丽[1] 吴艳[1] 高剑波[1] SU Lei;LIANG Pan;CHANG Liyang;HU Lili;WU Yan;GAO Jianbo(Department of Radiology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Chin)

机构地区：[1]郑州大学第一附属医院放射科,河南郑州450052

出　　处：《中国医学影像技术》2018年第8期1233-1236,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨能谱CT定量参数值评估Budd-Chiari综合征(BCS)患者肝功能分级的临床价值。方法采用能谱CT对81例BCS患者行双期增强扫描,测量并计算门静脉期肝脏Ⅰ~Ⅷ段及脾脏的碘基值(IC)及标准化碘基值(NIC),比较不同Child-Pugh肝功能等级患者(Child-Pugh A级30例,B级27例,C级24例)间NIC的差异。记录患者的凝血酶原时间(PT)、白蛋白(ALB)、总胆红素(TBIL)、谷草转氨酶(AST)和谷丙转氨酶(ALT),分析不同肝功能等级BCS患者肝脏NIC与肝功能实验室指标间的相关性。结果不同肝功能分级患者之间,肝脏Ⅰ、Ⅲ段和脾脏的NIC总体差异有统计学意义(P=0.031、0.045、0.008)。肝功能A级患者肝脏Ⅰ、Ⅲ段的NIC高于C级(P均<0.05),A级与B级、B级与C级间差异均无统计学意义(P均>0.05);肝功能A级患者脾脏NIC大于B级和C级(P=0.037、0.017),B级与C级间差异无统计学意义(P=0.073)。不同肝功能等级BCS患者肝脏NIC与PT及TBIL呈负相关(P均<0.05),与ALB呈正相关(P均<0.05),与ALT和AST无相关(P均>0.05)。结论能谱CT定量测量NIC有助于评估BCS患者肝功能状态。Objective To investigate the clinical value of quantitative parameters of spectral CT in evaluating liver function of patients with Budd-Chiari syndrome（BCS）.Methods Totally 81 patients with BCS underwent dual-phase enhanced CT with spectral CT.The iodine concentration（IC）and normalized iodine concentration（NIC）were measured and calculated onⅠ—Ⅷ segments of hepatic parenchyma and spleen,then NIC was compared among patients with different degrees of liver functions（Child-Pugh A grade 30 patients,B grade 27 patients,C grade 24 patients）.Prothrombin time（PT）,albumin（ALB）,total bilirubin（TBIL）,aspartate transaminase（AST）and alanine transaminase（ALT）of these patients were recorded.The correlation between liver NIC and each clinical indicators in BCS patients with different liver function were analyzed.Results There were significant differences of NIC in hepatic segments ofⅠ,Ⅲ and spleen in BCS patients with different liver functions（P=0.031,0.045,0.008）.There was no significant difference in hepatic segments ofⅠand Ⅲin patients with different types of BCS except between grade A and C（both P〈0.05）.NIC of spleen in grade A was higher than that in grades B and C（P=0.037,0.017）,and there was no significant difference between grade B and grade C（P=0.073）.NIC of liver in BCS patients with different liver functions showed negative correlation with PT and TBIL（all P〈0.05）and positive correlation with ALB（all P〈0.05）.There was no correlation of liver NIC with ALT nor AST（all P〉0.05）.Conclusion The spectral quantitative parameters of spectral CT may be helpful to evaluating liver function in patients with BCS.

关 键 词：布加综合征 体层摄影术 X线计算机 能谱成像 血管造影术 

分 类 号：R657.34[医药卫生—外科学] R814.42[医药卫生—临床医学]