原发性高血压患者踝臂指数、同型半胱氨酸水平与颈动脉粥样硬化相关性研究  

Relationship between Ankle Brachial Index, Homocysteine Level and Carotid Atherosclerosis in Patients with Essential Hypertension

作　　者：陈莹[1] 吴艳婷 范丽娟[2] 黄裕立[3] CHEN Ying;WU Yan-ting;FAN Li-juan;HUANG Yu-li(Medical Examination Center,Shunde Hospital Affiliated to Southern Medical University,Shunde,Guangdong Province,528300 China;The Second Outpatient Department of Shunde Hospital Affiliated to Southern Medical Uni-versity,Shunde,Guangdong Province,528300 China;Department of Cardiology,Shunde Hospital Affiliated to Southern Medical University,Shunde,Guangdong Province,528300 China)

机构地区：[1]南方医科大学附属顺德医院体检中心,广东顺德528300 [2]南方医科大学附属顺德医院第二门诊部,广东顺德528300 [3]南方医科大学附属顺德医院心内科,广东顺德528300

出　　处：《系统医学》2018年第8期64-67,共4页Systems Medicine

基　　金：佛山市医学类科技攻关项目(2015AB002183)

摘　　要：目的探讨原发性高血压患者踝臂指数(ankle brachial index,ABI)、同型半胱氨酸(homocysteine,HCY)水平与颈动脉粥样硬化的相关性。方法选取100例原发性高血压患者,他们均是2016年3月—2017年4月被南方医科大学附属顺德医院收治的。对患者进行超声检测颈动脉内膜,根据结果分为斑块组和非斑块组各50例。其中50例斑块组患者根据斑块稳定性质分为稳定性斑块组和易损斑块组,分别为27例、23例。所有患者接受ABI、血浆HCY的检测,并对检测结果进行对比分析。所得数据采用SPSS 19.0统计学软件进行数据处理,并以颈动脉粥样硬化斑块性质为自变量,以ABI与血浆HCY为应变量,对其进行进一步相关性分析。结果斑块组患者ABI(0.72±0.24)显著低于无斑块组患者(1.19±0.51);斑块组患者HCY(19.11±5.62)μmol/L明显高于无斑块组(12.26±2.47)μmol/L,差异有统计学意义(P<0.05)。易损斑块组患者的ABI与稳定性斑块组差异无统计学意义(t=0.504,P=0.616);易损斑块组患者血浆HCY水平(23.15±6.85)μmol/L显著高于稳定性斑块组(18.13±3.06)μmol/L,差异有统计学意义(t=3.431,P=0.001)。相关性分析结果显示:颈动脉粥样硬化斑块稳定性与ABI无关(P>0.05),但与血浆HCY呈负相关性(r=0.653,P<0.01)。结论原发性高血压患者踝臂指数、同型半胱氨酸水平与颈动脉粥样硬化形成相关,同型半胱氨酸水平与斑块稳定性呈负相关性。Objective This paper tries to investigate the correlation between ankle brachial index（ABI） and homocysteine（HCY） level and carotid atherosclerosis in patients with primary hypertension. Methods 100 cases of patients with primary hypertension treated in Shunde Hospital Affiliated to Southern Medical University from March 2016 to April 2017 were selected as research objects. The patient underwent ultrasound examination of the intima of the carotid artery. According to the results, they were divided into plaque group（n=50） and non plaque group（n=50）. According to the stability of plaque, 50 cases of plaque group were divided into stable plaque group and vulnerable plaque group, 27 cases and 23 cases, respectively. All patients were tested for ABI and plasma HCY, and the results were compared and analyzed. The data were processed by SPSS 19.0 software. Taking carotid atherosclerotic plaque as independent variable and ABI and plasma HCY as dependent variables, further correlation analysis was carried out. Results ABI（0.72±0.24）was significantly lower in the plaque group than in the non-plaque group（1.19±0.51）;HCY（19.11±5.62）μmol/L was significantly higher in the plaque group than in the plaque-free group（12.26±2.47）μmol/L the difference was statistically significant（P〈0.05）. There was no statistically significant difference between the ABI group and the stable plaque group in the vulnerable plaque group（t=0.504, P=0.616）; the plasma HCY level（23.15±6.85）μmol/L was significantly higher in the vulnerable plaque group. In the stable plaque group（18.13±3.06）μmol/L, the difference was statistically significant（t=3.431, P=0.001）. Correlation analysis showed that the stability of carotid atherosclerosis plaque was not related to ABI（P〉0.05）, but negatively correlated with plasma HCY（r=0.653, P〈0.01）. Conclusion In patients with essential hypertension, ankle-brachial index and homocysteine levels are associated with the formation of carotid atheroscl

关 键 词：同型半胱氨酸 原发性高血压 踝臂指数 颈动脉粥样硬化 

分 类 号：R544.1[医药卫生—心血管疾病]