输尿管镜手术围术期应用盐酸坦索罗辛临床价值分析  

Clinical value analysis of tamsulosin hydrochloride in perioperative period of ureteroscopy

作　　者：李杰[1] 余思源[1] LI Jie;YU Siyuan(Department of Urology Surgery,People’s Hospital of Luxian County,Luxian 646106,China)

机构地区：[1]四川泸县人民医院泌尿外科,四川泸县646106

出　　处：《现代仪器与医疗》2018年第3期38-40,共3页Modern Instruments & Medical Treatment

摘　　要：目的 :分析输尿管镜手术围术期应用盐酸坦索罗辛的临床价值,总结应用体会。方法 :2015年6月至2017年4月130例行输尿管镜下碎石术的输尿管结石患者随机分为TH组、C组,TH组术前3 d至术后7 d口服盐酸坦索罗辛。比较两组患者手术情况、术中疼痛、术后不良反应发生率、结石清除率,以及输尿管支架管相关症状问卷(USSQ)评分,观察盐酸坦索罗辛药物不良反应。结果 :TH组置管时间、手术时间、术中肾盂压力均低于C组,其一次性置管成功率高于后者,差异有统计学意义(P<0.05)。TH组术中VAS评分低于C组,差异有统计学意义(P<0.05)。TH组术后腰腹痛、下尿路症状发生率分别为16.92%、7.69%,均低于C组的40.00%、21.54%,差异有统计学意义(P<0.05)。TH组术后各观测时点结石清除率及术后2周结石总清除率均高于C组,差异有统计学意义(P<0.05)。术后7 d,TH组USSQ问卷各条目评分均低于C组,差异有统计学意义(P<0.05)。结论 :输尿管镜手术围术期应用盐酸坦索罗辛能够明显降低置镜难度、缩短恢复时间、提高结石排出率。Objective： The objective of this study was to analyze the clinical value of tamsulosin hydrochloride in perioperative period of ureteroscopy, and to summarize its application experience. Methods： A sample of 130 ureteral calculus patients with ureteroscopic lithotripsy from June 2015 to April 2017 were randomly divided into TH group and C group. TH group was treated with tamsulosin hydrochloride 3d befroe operation and 7d after operation. The operation situations, intraoperative pain, incidences of postoperative adverse reactions, stone clearance rates, and scores of ureteral stent related symptom questionnaire （USSQ） were compared between the two groups, and the adverse drug reactions of tamsulosin hydrochloride were observed. Results： The indwelling time of tube, operation time and intraoperative pressure of renal pelvis in TH group were lower than those in C group, and the success rate of disposable indwelling tube in TH group was higher than that in C group, the difference was statistically signifcant （P〈0.05）. The intraoperative VAS score in TH group was lower than that in C group, and the difference was statistically signifcant （P〈0.05）. The incidences of postoperative abdominal pain and lower urinary tract symptoms in TH group were 16.92% and 7.69% respectively, which were lower than those in C group （40% and 21.54%）, and the difference was statistically signifcant （P〈0.05）. In TH group, the stone clearance rates at postoperative observation time points and the total clearance rate of stones at 2 weeks after operation were all higher than those in C group C （P〈0.05）. At 7d after operation, the scores of each item in USSQ in TH group were lower than those in C group （P〈0.05）. Conclusions： The application of tamsulosin hydrochloride in perioperative period of ureteroscopy can signifcantly reduce the diffculty of placing the mirror, shorten the recovery time and improve the stone excretion rate.

关 键 词：输尿管镜 围术期 盐酸坦索罗辛 

分 类 号：R693[医药卫生—泌尿科学]