生理盐水与肝素钠盐水在尿动力学检查中预防堵管的效果比较  

Comparison of the effect of saline and heparin saline in the prevention of tube blockage during urodynamic examination

作　　者：杨秋香[1] 曾骁[1] 杨清荣[1] YANG Qiuxiang;ZENG Xiao;YANG Qingrong(Department of Urology,West China Hospital,Sichuan University,Urology Research Institute,Chengdu 610041,China)

机构地区：[1]四川大学华西医院泌尿外科.泌尿外科研究所,四川成都610041

出　　处：《西部医学》2018年第8期1229-1232,共4页Medical Journal of West China

基　　金：四川省科技厅科技支撑计划项目(2013SZ00583)

摘　　要：目的比较生理盐水与肝素钠盐水在尿动力学检查中预防堵管的效果。方法将2015年3月~2016年5月收治的行临床尿动力学检查患者90例随机分为对照组(应用普通生理盐水冲洗管道)和研究组(应用肝素钠盐水冲洗管道)各45例。观察检查前后两组凝血功能指标[凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)]和血小板计数(PLT)及视觉模拟疼痛评分(VAS)变化,并比较两组导管使用时间、封管时间、出血率、堵管率及导管相关并发症发生情况。结果检查前,两组PT、APTT、PLT、VAS评分比较,差异无统计学意义(P>0.05);与检查前比较,检查后仅研究组PT、APTT明显延长,并且研究组PT、APTT变化较对照组明显(P<0.05);但检查后两组PLT比较,差异无统计学意义(P>0.05);检查后1、3、5d两组VAS评分较检查前明显降低,但研究组降低幅度较对照组更明显(P<0.05);研究组导管使用时间、封管时间较对照组短(P<0.05);研究组堵管率和导管内血栓发生率较对照组低(P<0.05);两组出血率和导管功能不良及导管相关性感染发生率相比,差异无统计学意义(P>0.05)。结论肝素钠盐水在临床尿动力学检查中应用时,在不增加出血风险的情况下,其抗凝、缓解患者疼痛、缩短导管使用时间、封管时间和降低堵管率及并发症发生率等的效果均较普通生理盐水更具优势。Objective To compare the effect of saline and heparin sodium saline on urodynamic study.Methods90 patients undergoing urodynamic examination in the hospital from March 2015 to May 2016 were randomly divided into the control group（flushing the pipe with normal saline）and the study group（flushing the pipe with heparin sodium saline）,45 patients in each group.Changes of coagulation indexes[prothrombin time（PT）,activated partial thromboplastin time（APTT）],platelet count（PLT）and visual analogue scores（VAS）in the two groups before and after examination were observed.The catheter use time,catheter sealing time,bleeding rate,plugging rate and the incidence of catheter related complications were compared between the two groups.Results There was no significant difference in PT,APTT,PLT and VAS score between the two groups before examination（P〉0.05）.After examination,the PT and APTT only in the study group were significantly prolonged,and the changes of PT and APTT in the study group were significantly greater than those in the control group（P〈0.05）.However,there was no significant difference between the two groups in PLT after examination（P〉0.05）.VAS scores of the two groups at 1 day,3 days and 5 days after examination were significantly lower than those before the examination,and the decrease in study group was significantly greater than that in the control group（P〈0.05）.The catheter use time and sealing time of the study group were significantly shorter than those of the control group（P〈0.05）.The plugging rate and the incidence of catheter thrombosis in the study group were significantly lower than those in the control group（P〈0.05）but there was no significant difference in the incidence of bleeding,catheter dysfunction and catheter-related infections between the two groups（P〈0.05）.Conclusion The application of heparin sodium saline has more advantages over normal saline in clinical urodynamic examination in anticoagulation,relieving pain of patients,short

关 键 词：尿动力学检查 生理盐水 肝素钠 堵管 

分 类 号：R69[医药卫生—泌尿科学]