阿托伐他汀钙片联合阿司匹林肠溶片治疗脑血栓患者颈动脉斑块的临床研究  

Clinical trial of atorvastatin calcium tablets combined with aspirin enteric-coated tablets in the treatment of carotid artery plaque in patients with cerebral thrombosis

作　　者：聂建军[1] 盛晓燕[2] 杨璐 NIE Jian-jun;SHENG Xiao-yan;YANG Lu(Department of Parmacy,First Affiliated Hospital of Nanyang Medical College,Nanyang 473058,Henan Province,China;Nursing Faculty,Nanyang Medical College,Nanyang 473058,Henan Province,China;Department of Parmacy,Nanyang Third People＇ s Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳医学高等专科学校第一附属医院药剂科,河南南阳473058 [2]南阳医学高等专科学校护理系,河南南阳473058 [3]南阳市第三人民医院药剂科,河南南阳473000

出　　处：《中国临床药理学杂志》2018年第15期1758-1761,共4页The Chinese Journal of Clinical Pharmacology

基　　金：河南省科技攻关计划基金资助项目(172102310219)

摘　　要：目的观察阿托伐他汀钙片联合阿司匹林肠溶片对脑血栓患者颈动脉斑块的影响。方法将120例脑血栓患者随机分为2组,每组60例。对照组,睡前口服阿司匹100 mg,每天1次;试验组在对照组的基础上,加用阿托伐他汀钙片每次10 mg,每天1次,2组均连用2周。进行蒙特利尔认知评估量表(Mo CA)调查;用弥散张量成像(DTI)测量各向异性分数(FA)和平均扩散系数(MD);用磁共振血流量扫描(MRS)测定胆碱化合物(Cho)、肌酸酐复合物(Cr)、肌醇(m I)以及N-乙酰基天门冬氨酸(NAA)峰值,并计算NAA/Cr、Cho/Cr、m I/Cr的比值;对比2组患者的临床疗效。结果治疗后,试验组与对照组的Mo CA总分分别是(27.32±1.29),(23.18±1.34)分;这2组的左侧颞叶m I/Cr值分别是0.47±0.08,0.52±0.07;这2组的右侧额叶NAA/Cr值分别是1.56±0.41,1.44±0.09,组间比较差异均有统计学意义(均P<0.05);试验组与对照组的总有效率分别是91.67%(55例/60例),80.00%(48例/60例),组间比较差异有统计学意义(P<0.05)。结论阿托伐他汀钙片联合阿司匹林肠溶片治疗脑血栓患者,可改善明显颈动脉斑块与生存质量。Objective To observe the effect of atorvastatin calcium tablets combined with aspirin enteric-coated tablets in the treatment of carotid artery plaque in patients with cerebral thrombosis. Methods One hundred and twenty cases of cerebral thrombosis were randomly divided into two groups（ 60 cases in each group）. Control group was given aspirin by oral administration before going to bed,100 mg for each time,qd;on the basis of control group,the treatment group was given atorvastatin calcium tablets,10 mg orally,once daily,two groups received continuous medication for 2 weeks. The Montreal cognitive assessment（ Mo CA）scores in two groups were investigated. The mean diffusivity（ MD）,fractional anisotropy（ FA） value in two groups were determined by diffusion tensor imaging. The N-acetyl aspartate（ NAA）/creatine complex（ Cr）,choline compound（ Cho）/Cr,myo-inositol（ m I）/Cr values in two groups were determined by magnetic resonance spectroscopy. The total efficiency in two groups was compared. Results After treatment,the Mo CA scores of treatment group and control group were（ 27. 32 ± 1. 29）and（ 23. 18 ± 1. 34） points respectively; the m I/Cr values of the left temporal lobe in the 2 groups were 0. 47 ± 0. 08 and 0. 52 ± 0. 07; the NAA/Cr values of the right frontal lobe in the 2 groups were 1. 56 ± 0. 41 and 1. 44 ± 0. 09,respectively,and the differences were statistically significant（ all P 0. 05）. After treatment,the total effective rates of treatment group and control group were 91. 67 %（ 55 cases/60 cases） and 80. 00 %（ 48 cases/60 cases）,respectively; the difference between the two groups was statistically significant（ P 0. 05）. Conclusion Aspirin and atorvastatin calcium can improve the carotid plaques and the quality of life for patients with cerebral thrombosis.

关 键 词：脑血栓 颈动脉斑块 阿司匹林 阿托伐他汀钙 神经功能缺损评分 

分 类 号：R972.6[医药卫生—药品]