针刺治疗支气管哮喘急性发作的多靶点效应研究  

Study on multi-target effect of acupuncture in acute attack of bronchial asthma

作　　者：韩健[1] 芦珊珊[2] 肖俊艳 张心月[1] 贾新华[1] HAN Jianl;LU Shan-shan;XIAO Jun-yan;ZHANG Xin-yuel;JIA Xin-hua(Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250011,China;Jinan Hospital of Traditional Chinese Medicine,Jinan 250012,China)

机构地区：[1]山东中医药大学附属医院,济南250011 [2]济南市中医医院,济南250012

出　　处：《中华中医药杂志》2018年第8期3713-3715,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：山东省中医药科技发展计划项目(No.2013ZDZK-099);山东省人民政府"泰山学者"建设工程专项(No.ts20110819)~~

摘　　要：目的:探讨针刺对支气管哮喘(BA)急性发作平喘的多靶点机制。方法:选取BA急性发作住院患者190例,观察组96例,对照组94例。对照组:喷吸沙丁胺醇气雾剂200μg。观察组:针刺鱼际、孔最、定喘、肺俞,留针20min。检测肺功能指标、神经生长因子(NGF)、基质金属蛋白酶9(MMP-9)、辅助T细胞(Th细胞)。结果:(1)肺功能:治疗5min时两组肺功能均有改善(P<0.05),且对照组优于观察组(P<0.05)。20min时两组肺功能水平无显著差异。(2)NGF:对照组治疗后NGF无改善。与治疗前比较,观察组治疗5min无改善,治疗20min时显著优于治疗前(P<0.01)及同期对照组(P<0.05)。(3)MMP-9:与治疗前比较,治疗5min两组患者MMP-9均无改善,20min时两组患者均显著改善(P<0.05,P<0.01)。(4)Th1/Th17:对照组治疗后Th1/Th17无改善;观察组治疗5min无改善。20min时显著改善,优于治疗前及同期对照组(P<0.01)。结论:针刺鱼际、孔最、定喘、肺俞穴位并留针20min,可有效改善BA患者MMP-9、Th1/Th17、NGF等多靶点指标,从而改善肺功能。Objective： To investigate the multi-target mechanism of acupuncture on acute attack of bronchial asthma （BA）. Methods： A total of 190 patients with acute attack of BA were enrolled, with 96 cases in observation group and 94 cases in control group. The control group was inhaled salbutamol aerosol 200 μg. The observation group was acupunctured on Yuji （LUI0）, Kongzui （LU6）, Dingchuan （EX-B1）, Feishu （BL13） for 20 min. The indexes of lung function, nerve growth factor （NGF）, matrix metalloproteinase 9 （MMP-9） and Thl/Thl7 were detected. Results： ①Lung function： Lung function was improved at 5 min （P〈0.05）, while the control group was superior to the observation group （P〈0.05）. And at 20 min, the two groups had no significant difference. ②NGF： NGF in control group showed no significant improvement after treatment. In observation group, NGF had no significant improvement at 5min. While at 20 min node, NGF improved, which was better than before treatment （P〈0.01） and better than the control group （P〈0.05）. ③MMP-9： At 5 min node, two groups of patients had no significant improvement. At 20 rain node, MMP-9 in both groups improved compared with that before treatment （P〈0.05, P〈0.01）. ④Th1/Th17： After treatment, Th1/Th17 in control group had no significant improvement. On observation group, Thl/Thl7 had no significant improvement at 5 min node, while at 20 min node it was better than that before treatment and the control group （P〈0.01）. Conclusion： The acupuncture at the point Yuji （LU10）, Kongzui （LU6）, Dingchuan （EX-B1）, Feishu （BL13） for 20 min can effectively improve the multi-target indexes of MMP-9, Thl/Thl7 and NGF in patients with BA and improve the lung function.

关 键 词：支气管哮喘 针刺 神经生长因子 气道重塑 免疫应答 

分 类 号：R246.1[医药卫生—针灸推拿学]