残黄片利胆保肝作用的非临床药效学研究  

Nonclinical pharmacodynamic studies of study on the liver-protective and Choleretic effect of Canhuang tablets

作　　者：王雯颍 李承平 李娜娜 邓莉[1] 石金金[1] 陈慧芳[3] 孙曼[4] 何永侠 李寅超[1] 袁海龙[6] 韩晋[7] WANG Wen-ying;LI Cheng-ping;LI Na-na;DENG Li;SHI Jin-jin;CHENG Hui-fang;SUN Man;HE Yong-xia;LI Yin-chao;YUAN Hal-long;HAN Jin(School of Pharmaceutical Sciences of Zhengzhou University,Zhengzhou,450001,China;College of Life Sciences of Zhengzhou University,Zhengzhou,450001,China;First Affiliated Hospital of Xinxiang Medical College,Xinxiang Henan 453100,China;Zhengzhou First People＇ s Hospital,Zhengzhou 450004,China;Luoyang Polytechnic school,Luoyang,471000 China;General Hospital of the Air Force of the Chinese PLA,Belting 100036,China;Hospticatal 302 of PLA,Beijing 100039,China)

机构地区：[1]郑州大学药学院,河南郑州450001 [2]郑州大学生命科学学院,河南郑州450001 [3]新乡医学院第一附属医院,河南新乡453100 [4]郑州市第一人民医院,河南郑州450004 [5]洛阳职业技术学院,河南洛阳471000 [6]中国人民解放军空军总医院,北京100036 [7]中国人民解放军第302医院,北京100039

出　　处：《时珍国医国药》2018年第4期845-848,共4页Lishizhen Medicine and Materia Medica Research

基　　金：河南省中医药科学研究专项课题(2014ZY02017); 河南省科技计划项目(152102310072); 中国肝炎防治基金会-王宝恩肝纤维化研究基金资助课题(WEB20170066)

摘　　要：目的探讨残黄片的利胆作用,为残黄片的进一步研究开发提供试验依据。方法观察残黄片对正常小鼠胆汁分泌量的影响及对正常大鼠胆汁流量的影响;采用ANIT诱导胆汁淤滞性肝损伤大鼠模型,观察大鼠胆汁分泌量及胆汁中TBIL、DBIL和CHOL含量以及血液生化学指标(ALT、AST、TBIL、DBIL)的变化。结果残黄片可明显地促进正常大、小鼠和胆汁淤积性肝损伤模型大鼠胆汁的分泌,且能够降低肝损伤大鼠胆汁中的TBIL、DBIL和血清中的水平,显示出较强的利胆作用和对胆管和肝细胞损伤的修复作用,残黄片高、中、低剂量呈量效关系。结论残黄片具有明显的利胆和保肝作用。Objective To explore the choleretic effect of Canhuang tablets and provide experimental basis for further research and development of Canhuang tablets. Methods The effects of residual yellow tablets on bile secretion in normal mice and rats and the effects on TBI,DBIL,CHOL and TBA were studied. The changes of bile secretion and TBIL,DBIL and CHOL contents and blood biochemical indexes（ALT,AST,TBIL,DBIL） in rats were observed by ANIT induced rat model of biliary obstructive liver injury. Results Canhuang tablets could significantly promote the secretion of bile in normal rats,rats and cholestatic liver injury rats,and could decrease the levels of TBIL,DBIL and serum ALT,AST,TBIL and DBIL in bile of rats with liver injury level,showing a strong role in the gallbladder and bile duct and liver cell damage repair role,Canhuang film high,medium and low dose was dose-effect relationship. Conclusion Canhuang tablets have obvious effect of choleretic and liver-protective.

关 键 词：残黄片 小鼠 大鼠 利胆 

分 类 号：R285.5[医药卫生—中药学]