Investigation of SPECT/CT cardiac imaging using Geant4  

作　　者：A.Alfuraih O.Kadri K.Alzimami 

机构地区：[1]Department of Radiological Sciences,College of Applied Medical Sciences,King Saud University,PO Box 10219,Riyadh 11433,Saudi Arabia [2]National Center for Nuclear Sciences and Technologies,2020 Tunis,Tunisia

出　　处：《Nuclear Science and Techniques》2018年第7期198-208,共11页核技术（英文）

基　　金：Supported by the College of Applied Medical Sciences Research Centre and the Deanship of Scientific Research at King Saud University of Saudi Arabia

摘　　要：The purpose of this paper is to propose a friendly computational framework able to investigate particles tracking through different compartments of the human being using dedicated numerical techniques.The main building blocks of this framework are:(i) convenient X-ray spectra calculator for different filter/anode combination,(ii) realistic voxelized computational human phantom,(iii)validated Geant4-based Monte Carlo simulation,and(iv)extendable and free image processing software.We studied the multimodality SPECT/CT cardiac imaging using specific spectrum of the ^(99m)Tc and 120 kVp X-ray beam,for internal and external exposure,respectively.The application of the framework to quantify the loss of information between combined and simultaneous coregistration was carried out.Two main objectives were addressed:(i) an ideal geometry was simulated for educational purposes(ii) a realistic case study was carried out,for research purposes,concerning the modeling of the GE Infinia II 3/800 Gamma Camera.We compared the effect of using a Na I(Tl) and CZT crystal detector,and a LEHR and MEGP collimator with different uptake values of the heart organ(1:1,5:1 and 50:1) for both simultaneous andcombined SPECT/CT images.We confirmed the usefulness of the Na I(Tl) crystal with the LEHR collimator for such kind of study.The purpose of this paper is to propose a friendly computational framework able to investigate particles tracking through different compartments of the human being using dedicated numerical techniques. The main building blocks of this framework are： （i） convenient X-ray spectra calculator for different filter/anode combination, （ii） realistic voxelized computational human phantom, （iii） validated Geant4-based Monte Carlo simulation, and （iv） extendable and free image processing software. We studied the multimodality SPECT/CT cardiac imaging using specific spectrum of the 99mTc and 120 kVp X-ray beam, for internal and external exposure, respectively. The application of the framework to quantify the loss of information between combined and simultaneous coregistration was carried out. Two main objectives were addressed： （i） an ideal geometry was simulated for educational purposes （ii） a realistic case study was carried out, for research purposes, concerning the modeling of the GE Infinia Ⅱ 3/8＂ Gamma Camera. We compared the effect of using a NaI（T1） and CZT crystal detector, and a LEHR and MEGP collimator with different uptake values of the heart organ （1：1, 5：1 and 50：1） for both simultaneous andcombined SPECT/CT images. We confirmed the usefulness of the NaI（T1） crystal with the LEHR collimator for such kind of study.

关 键 词：GEANT4 成像 心脏 图象处理软件 计算框架 蒙特卡罗模拟 现实主义 GAMMA 

分 类 号：R816.2[医药卫生—放射医学] TP391.41[医药卫生—临床医学]