急性冠状动脉综合征严重程度与血浆N末端B型利钠肽原浓度相关性的研究  

Research on Correlation between the Severity Degree of Acute Coronary Syndrome and Plasma N Terminal B Natriuretic Peptide Concentration

作　　者：王斌[1] 吴春阳[1] 施亚明[1] 杨顺清[1] 施国富[1] 周召峰[1] 陈荣敏[1] WANG Bin;WU Chun-yang;SHI Ya-ming;YANG Shun-qing;SHI Guo-fu;ZHOU Zhao-feng;CHEN Rong-min(Department of Cardiology, Yancheng Third People＇s Hospital; Yancheng,JiangsuProvince,224001China)

机构地区：[1]江苏省盐城市第三人民医院心内科,江苏盐城224001

出　　处：《中外医疗》2018年第13期43-45,48,共4页China & Foreign Medical Treatment

摘　　要：目的探讨急性冠状动脉综合征(ACS)的严重程度与患者血浆的N末端B型利钠肽原(NT-proBNP)浓度是否存在相关性,分析NT-proBNP浓度能否作为判断患者急性冠状动脉综合征严重程度的生化标准。方法方便选取2015年1月—2017年12月期间诊治急性冠状动脉综合征患者共计91例作为研究对象,采集患者静脉血样,予以NT-proBNP检测,UA患者分级为BraunwaldⅠ级、BraunwaldⅡ级以及BraunwaldⅢ级;AMI患者分级为KillipⅠ级、KillipⅡ级以及KillipⅢ级。结果 UA组患者血浆的NT-proBNP水平与患者心绞痛分级(Braunwald)呈现正相关关系,Ⅰ级患者的NT-proBNP、TNI、CK-MB分别为(456.26±401.23)ng/L、(0.04±0.01)μg/L以及(1.42±0.81)U/L;Ⅱ级患者的NT-proBNP、TNI、CK-MB分别为(532.19±526.24)ng/L、(0.03±0.02)μg/L以及(1.19±1.09)U/L;Ⅲ级患者的NTproBNP、TNI、CK-MB分别为(682.61±603.57)ng/L、(0.07±0.05)μg/L以及(4.34±9.24)U/L。AMI组患者血浆的NTproBNP水平会随着患者Killip的心脏功能分级的逐渐增高而不断增大。Ⅰ级患者的NT-proBNP、TNI、CK-MB分别为(984.36±771.26)ng/L、(10.89±10.06)μg/L以及(13.57±10.27)U/L;Ⅱ级患者的NT-proBNP、TNI、CK-MB分别为(1365.72±657.34)ng/L、(9.86±11.24)μg/L以及(17.65±22.14)U/L;Ⅲ级患者的NT-proBNP、TNI、CK-MB分别为(1589.65±452.31)ng/L、(8.83±10.64)μg/L以及(26.98±34.26)U/L。结论急性冠状动脉综合征患者的血浆NT-proBNP水平与患者病情的严重程度存在显著的相关性。Objective To study the correlation between the severity degree of acute coronary syndrome and plasma N terminal B natriuretic peptide concentration and analyze whether the NT-proBNP concentration can be used as the biochemical standards of determining the severity degree of acute coronary syndrome. Methods 91 cases of patients with acute coronary syndrome admitted and treated in our hospital from January 2015 to December 2017 were convenient selected and the intravenous blood samples were collected for NT-proBNP test, and the UA classification showed that there were level BraunwaldⅠ, level BraunwaldⅡ and level BraunwaldⅢ, and the AMI patients included the level KillipⅠ, level KillipⅡand level KillipⅢ. Results The NT-proBNP level of blood plasma of UA group is positively correlated with the Braunwald,and the NT-proBNP, TNI, CK-MB of patients in level I were respectively（456.26 ±401.23） ng/L,（0.04±0.01）μg/L,（1.42±0.81）U/L and of patients in level II were respectively（532.19±526.24） ng/L,（0.03±0.02）μg/L,（1.19±1.09）U/L and of patients in level III were respectively（682.61±603.57）ng/L,（0.07±0.05）μg/L,（4.34±9.24）U/L, with the gradual increase of cardiac function classification of Killip, the NT-proBNP level of plasma in the AMI group constantly increased, and the NT-proBNP, TNI, CK-MB of patients in level I were respectively（984.36±771.26）ng/L,（10.89±10.06）ug/L,（13.57±10.27）U/L, and of patients in level II were respectively（1 365.72 ±657.34）ng/L,（9.86±11.24）μg/L,（17.65±22.14）U/L and of patients in level III were respectively（1 589.65±452.31）ng/L,（8.83±10.64）ug/L,（26.98±34.26）U/L. Conclusion The plasma NT-proBNP level of patients with acute coronary syndrome is obviously correlated with the severity degree of diseases of patients.

关 键 词：急性冠脉综合征 N末端B型利钠肽原 相关性 浓度 

分 类 号：R5[医药卫生—内科学]