普瑞巴林联合依托考昔治疗梨状肌综合征的疗效观察  

Effect of Combined Treatment of Pregabalin and Etoricoxib on Piriformis Syndrome

作　　者：林涛[1] 江平[1] 刘柳[1] 李祥奎[1] 宋俊梅[2] Lin Tao;Jiang Ping;Liu Liu;Li Xiangteui;Song Junmei(Department of Anesthesiology;Cardiac Function Division,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital,Chengdu 610072,China)

机构地区：[1]四川省人民医院.四川省医学科学院麻醉科,成都610072 [2]四川省人民医院.四川省医学科学院心功能科,成都610072

出　　处：《成都医学院学报》2018年第4期477-479,共3页Journal of Chengdu Medical College

摘　　要：目的观察口服普瑞巴林联合依托考昔治疗梨状肌综合征的临床疗效。方法选取四川省人民医院2016年9月至2017年9月疼痛科收治的梨状肌综合征患者80例,随机分为观察试验组和对照组,每组40例。对照组给予口服依托考昔60mg,每日1次,试验组给予口服普瑞巴林75mg,每日2次和依托考昔60mg,每日1次。两组患者均治疗2周。观察并比较治疗后第1、2、3、7、10、14天静息状态下两组视觉模拟评分(visual analogue scale,VAS)、治疗后14d测评治疗整体满意度,并记录两组患者不良反应的发生情况。结果试验组治疗后第3、7、10、14天的VAS值明显低于对照组患者(P<0.05)。试验组治疗后镇痛满意度为82.5%,对照组治疗后镇痛满意为65.0%,试验组明显高于对照组(P<0.05)。治疗开始第1、2天两组的VAS评分比较,差异无统计学意义(P>0.05),药品不良反应的发生率试验组低于对照组(P<0.05)。结论普瑞巴林联合依托考昔治疗具有良好的镇痛效果,用于梨状肌综合征的治疗效果较单用依托考昔,且不良反应发生也较单用依托考昔少。Objectives To observe the efficacy of combined treatment of pregabalin and etoricoxib on treatment of piriformis syndrome . Methods A total of 80 piriformis syndrome patients who admitted by pain treatment department of Sichuan People＇s Hospital from September 2016 to September 2017, were enrolled in this study. The patients were randomly designated into the experiment group （Group A） and the control group （Group B）, with 40 subjects in each group. Patients in Group B were given oral administration of etoricoxib （60mg, qd）, and Group A underwent oral administration of pregabalin（75mg, bid） and etoricoxib （60mg, qd） for a continuous 2 weeks. To observe and compare the visual analogies score （VAS） in the resting state at 1,2,3,7,10 and 14 days after treatment, and the values at 14 days posterior to treatment was used to evaluate the overall satisfaction. The adverse reactions of the two groups were recorded. Results The VAS values detected at 3, 7,10 and 14 days after treatment in group A （from 4.2 ± 1.32 to 1.21 ± 1.03）was significantly lower than that in group B （P〈0.05）. The response rates in Group A （82.5%） was significantly higher than that in group B （65.0 %）（P〈0.05）. However, there was no significant difference in VAS values and satisfaction scores between the two groups after 1 and 2 days of treatment （P〉0.05）. The occurrence of adverse drug reaction in group A was lower than that in group B（P〈0.05）. Conclusions The combination of pribalin and etoricoxib has a good analgesic effect , which can be used in piriformis syndrome treatment.

关 键 词：普瑞巴林 依托考昔 视觉模拟评分 梨状肌综合征 

分 类 号：R452[医药卫生—治疗学]