神经生长因子及其受体的表达在子宫内膜异位症患者中的临床意义  

Clinical significance of expression of nerve growth factor and its receptor in patients with endometriosis

作　　者：李著艳 王恒[2] LI Zhuyan;WANG Heng(Department of Gynaecology,Shiyan People’s Hospital,Shiyan,Hubei 442000,China;Department of Gynaecology,Shiyan Taihe Hospital,Shiyan,Hubei 442000,China)

机构地区：[1]湖北省十堰市人民医院妇科,湖北十堰442000 [2]湖北省十堰市太和医院妇科,湖北十堰442000

出　　处：《国际检验医学杂志》2018年第16期2005-2007,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨神经生长因子(NGF)及其受体TrkA、p75在子宫内膜异位症患者中的临床意义。方法随机选取2014年1月至2016年12月收治的子宫内膜异位症患者100例,其中腹壁子宫内膜异位结节(AEM)22例,卵巢子宫内膜异位囊肿(OEM)45例,宫骶韧带深部浸润型子宫内膜异位结节(DIE)33例,所有患者术前采用视觉模拟(VAS)评分法对术前疼痛进行评分,入组病例为评分在0分或10分的病例,并根据评分分为无疼痛组和疼痛组。应用免疫组织化学法对组织标本患者病灶中TrkA、p75及NGF的蛋白表达进行检测。另外选择20例同期子宫肌瘤且无疼痛患者的宫骶韧带组织作为对照组。结果与对照组比较,NGF及其受体TrkA、p75在AEM、OEM及DIE病灶中的表达均明显升高,差异均具有统计学意义(P<0.05);与AEM及OEM病灶比较,p75和NGF在DIE病灶中的表达明显升高,差异有统计学意义(P<0.05)。与无疼痛组的DIE、OEM患者比较,疼痛组OEM、DIE患者p75表达明显升高,差异具有统计学意义(P<0.05),而TrkA及NGF表达水平差异无统计学意义(P>0.05)。结论子宫内膜异位症的发生和发展与NGF及受体p75、TrkA的参与有关,子宫内膜异位症患者疼痛的发生与受体p75有关。Objective To explore the clinical significance of expression of nerve growth factor（NGF）and its receptor TrkA,p75 in patients with endometriosis.Methods A total of 100 cases of endometriosis treated from January 2014 to December 2016 in the hospital were selected,including 22 cases of abdominal endometriosis（AEM）,45 cases of ovarian endometriotic cyst（OEM）,33 cases of deep infiltration of endometriosis（DIE）.Preoperative visual acuity score（VAS）was conducted on all patients for preoperative pain.The patients with 0 or 10 points were enrolled in the study,and divided into painless group and pain group.Immunohistochemical method was used to detect the expression of TrkA,p75 and NGF in the tissue samples from lesion of patients.The uterosacral ligament tissue of 20 patients with concurrent uterine fibroids and no pain was selected as the control group.Results The expressions of NGF and its receptors TrkA,p75 in AEM,OEM and DIE lesions were significantly higher than those in normal palatal ligament tissue,and the differences were statistically significant（P〈0.05）.Compared with AEM and OEM lesions,the expressions of p75 and NGF in DIE lesions were significantly increased,and the difference was statistically significant（P〈0.05）.Compared with patients with DIE and OEM lesions in painless group,the expression of p75 in patients with DIE and OEM lesions in pain group was significantly higher,and the difference was statistically significant（P〈0.05）.There was no significant difference in the expression of TrkA and NGF（P〉0.05）.Conclusion The occurrence and development of endometriosis is related to the involvement of NGF and receptor p75 and TrkA.NGF and receptor p75 are closely related to DIE.The occurrence of pain in patients with endometriosis is related to receptor p75.

关 键 词：神经生长因子 子宫内膜异位症 受体 TRKA P75 

分 类 号：R711.71[医药卫生—妇产科学]