尿蛋白四项与IGF-1、MCP-1水平在过敏性紫癜患儿中的变化及与肾损伤的关系研究  

The relationship between four-item urinary protein testing and IGF-1 and MCP-1 levels in children with Henoch Schonlein purpura and renal damage

作　　者：张真如 ZHANG Zhenru(Department of Clinical Laboratory,Children′s Hospital of Xuzhou,Xuzhou,Jiangsu 221000,China)

机构地区：[1]徐州市儿童医院检验科,江苏徐州221000

出　　处：《国际检验医学杂志》2018年第16期2008-2010,2014,共4页International Journal of Laboratory Medicine

基　　金：徐州市科技局资助项目(XZZD1368)

摘　　要：目的探究尿蛋白四项[尿免疫球蛋白G(IgG)、尿微量清蛋白(MA)、尿α1-微球蛋白(α1-MG)、尿转铁蛋白(TRF)]与单核细胞趋化蛋白-1(MCP-1)、胰岛素样生长因子-1(IGF-1)水平在过敏性紫癜患儿中的变化及与肾损伤的关系。方法以该院2016年3月至2017年3月住院的60例过敏性紫癜患儿作为观察组,根据其是否发生肾损伤分为观察Ⅰ组(30例)和观察Ⅱ组(30例),同时选取体检健康的儿童60例作为对照组。对各组尿蛋白四项、MCP-1、IGF-1水平进行检测和比较。结果观察组尿蛋白四项和IGF-1、MCP-1水平均显著高于对照组,差异有统计学意义(P<0.05);观察Ⅰ组尿蛋白四项和IGF-1、MCP-1水平均高于观察Ⅱ组(P<0.05);在不同肾损伤分级患儿之间,尿蛋白四项水平差异无统计学意义(P>0.05),但IGF-1和MCP-1水平随肾损伤分级的增加而升高(P<0.05)。结论尿蛋白四项可以作为诊断过敏性紫癜的早期灵敏指标,IGF-1、MCP-1共同参与了过敏性紫癜导致肾损伤的过程。Objective To investigate the changes of four-item urinary protein testing,including urine immunoglobulin G（IgG）,urine microalbumin（MA）,urine alpha 1-microglobulin（alpha 1-MG）,urinary transferrin（TRF）and the levels of monocyte chemoattractant protein-1（MCP-1）and insulin-like growth factor-1（IGF-1）in children with Henoch Schonlein purpura（HSP）and their relationship with renal damage.Methods 60 cases of HSP admitted in the hospital from March 2016 to March 2017 were selected as the observation group.According to the occurrence of renal injury,they were divided into observation group I（30 cases）and observation group II（30 cases）.60 healthy children who underwent the health assessment in the hospital were selected as the control group.The levels of four items of urinary protein,MCP-1 and IGF-1 were detected and compared.Results The four items of urine protein（IgG,MA,alpha 1-MG and TRF）and IGF-1 and MCP-1 levels in the observation group were significantly higher than those in the control group,and the differences were statistically significant（P〈0.05）.The four items of urine protein（IgG,MA,alpha 1-MG and TRF）and IGF-1 and MCP-1 levels in observation group I were higher than those in the observation group II（P〈0.05）.There was no statistically significance in the four items of urine protein（IgG,MA,alpha 1-MG and TRF）levels in the children with different renal damage classification（P〉0.05）,but IGF-1 and MCP-1 levels increased with the increase of the renal damage classification（P〈0.05）.Conclusion The four items of urine protein（IgG,MA,alpha 1-MG and TRF）and IGF-1 and MCP-1 levels can be used as an early sensitive indicator for the diagnosis of HSP.IGF-1 and MCP-1 are involved in the process of renal injury caused by Henoch Schonlein purpura.

关 键 词：尿蛋白 胰岛素样生长因子-1 单核细胞趋化蛋白-1 过敏性紫癜 肾损伤 

分 类 号：R692.34[医药卫生—泌尿科学]