血小板-白细胞聚集体在急性心肌梗死合并心力衰竭患者中的临床价值研究  

Clinical value of platelet leukocyte aggregates in patients with acute myocardial infarction complicated with heart failure

作　　者：尹晓姝[1] Yin Xiaoshu(The People＇s Hospital of Ganzhou City,Ganzhou,Jiangxi 341000)

机构地区：[1]赣州市人民医院,江西赣州341000

出　　处：《基层医学论坛》2018年第25期3499-3500,共2页The Medical Forum

基　　金：赣州市指导性科技计划项目(GZ2017ZSF241)

摘　　要：目的研究血小板-白细胞聚集体在急性心肌梗死合并心力衰竭患者中的临床价值。方法将2016年6月—2017年7月我院就诊的180例急性心肌梗死合并心力衰竭患者设为研究组,抽取同期50名健康者设为对照组。检测2组研究对象血小板-白细胞聚集体(PLA)水平、C-反应蛋白(CRP)、血小板聚集率(PAg T)、降钙素原、肌钙蛋白、肌酸激酶同工酶等,分析PLA水平对身体基线指标的影响。采用美国国立卫生研究院卒中量表(NIHSS)对心肌梗死合并心力衰竭患者身体功能缺损进行评分后分为高风险组、中风险组和低风险组,分析各组患者PLA水平高低对急性心肌梗死合并心力衰竭的影响。结果研究组PLA、CRP、PAg T、降钙素原、肌钙蛋白、肌酸激酶同工酶明显升高,差异具有统计学意义(P<0.05)。高风险组的PLA水平高于中风险组,中风险组的PLA水平高于低风险组,差异具有统计学意义(P<0.05)。结论血小板-白细胞聚集体可以成为急性心肌梗死合并心力衰竭患者预后评估中的观察指标,对于指导治疗、改善预后、降低病死率具有重要意义,有很高的临床价值。Objective To study the clinical value of platelet leukocyte aggregate in patients with acute myocardial infarction complicated with heart failure. Methods From June 2016 to July 2017,180 cases of acute myocardial infarction complicated with heart failure were analyzed retrospectively.180 patients were included in the study group,and50 healthy persons were selected as the control group. The levels of platelet aggregation（PLA）,C-reactive protein（CRP）,platelet aggregation rate（PAg T）,calcitonin,troponin and creatine kinase isoenzyme were detected in two groups of subjects. The effects of PLA on body baseline were analyzed. The National Institutes of Health Stroke Scale（NIHSS）was used to score the body functional defects in patients with myocardial infarction and heart failure,which were divided into three groups of high risk group,middle risk group and low risk group,and the effect of PLA level on the different degree of acute myocardial infarction and heart failure in each group was analyzed. Results The PLA,C-reactive protein（CRP）,platelet aggregation rate（PAg T）,calcitonin,troponin and creatine kinase isoenzyme were significantly increased in the study group,with statistical significance（P〈0.05）.The PLA level of the high-risk group was higher than that of the middle risk group. The PLA level of the middle risk group was higher than that of the low risk group,and the difference was statistically significant（P〈0.05）.Conclusion Platelet white cell aggregates（PLA）can be an important prognostic indicator in the diagnosis of acute myocardial infarction and heart failure. It is of great significance for the correct treatment of acute myocardial infarction with heart failure,to improve the prognosis and to reduce the mortality rate. It is of high clinical value and is worth widely popularizing.

关 键 词：急性心肌梗死 心力衰竭 血小板-白细胞聚集体 临床价值 

分 类 号：R541.6[医药卫生—心血管疾病] R542.22[医药卫生—内科学]