慢性阻塞性肺疾病稳定期患者血清PCT、IL-6、hs-CRP、PSP/Reg水平变化对病情的预测价值  

Predictive Value of Serum Levels of PCT,IL-6,hs-CRP and PSP/Reg in Patients with Stable Chronic Obstructive Pulmonary Disease

作　　者：郭义娟 朱晖 韩永生 王颖[2] 刘英宇[2] GUO Yijuan;ZHU Hui;HAN Yongsheng;WANG Ying;LIU Yingyu(Department Six of Internal Medicine,Yutian County Hospital,Tangshan Hebei,064100,China)

机构地区：[1]唐山市玉田医院内六科,河北唐山064100 [2]唐山工人医院呼吸内科

出　　处：《解放军预防医学杂志》2018年第4期455-458,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：河北省中医药管理局科研计划项目(No.2015262)

摘　　要：目的探讨慢性阻塞性肺疾病稳定期患者血清PCT、IL-6、hs-CRP、PSP/Reg水平变化对病情的预测价值。方法选择106例COPD患者为观察组,同期45例健康查体患者为对照组,比较两组血清PCT、IL-6、hs-CRP、PSP/Reg水平和肺功能,对观察组患者进行为期一年的随访,记录慢性阻塞性肺疾病急性加重(AECOPD)的发生情况,并比较急性加重患者和非急性加重患者血清PCT、IL-6、hs-CRP、PSP/Reg水平和肺功能,进一步探讨血清PCT、IL-6、hs-CRP、PSP/Reg单独检测和联合检测对慢性阻塞性肺疾病急性加重的预测价值。结果观察组稳定期患者血清PCT、IL-6、hs-CRP、PSP/Reg水平显著高于对照组,肺功能指标显著低于对照组(P<0.05);随访一年间,发生AECOPD的人数为93例,AECOPD发生率为87.74%(93/106);急性加重患者PCT、IL-6、hs-CRP、PSP/Reg含量显著高于无急性加重患者,肺功能显著低于无急性加重患者(P<0.05);COPD稳定期血清PCT、IL-6、hs-CRP、PSP/Reg含量和肺功能呈负相关,和AECOPD发生率呈正相关(P<0.05);COPD稳定期血清PCT、IL-6、hs-CRP、PSP/Reg联合检测对AECOPD的敏感度和特异度高于四者的单一检测。结论 COPD稳定期患者血清PCT、IL-6、hs-CRP、PSP/Reg含量和肺功能呈负相关,和AECOPD发生率呈正相关。COPD稳定期患者血清PCT、IL-6、hs-CRP、PSP/Reg联合检测可提高AECOPD的预测准确性。Objective To investigate the predictive value of serum PCT,IL-6,hs-CRP and PSP/Reg levels in patients with stable chronic obstructive pulmonary disease（ COPD）. Methods One hundred and six patients with COPD were selected as the observation group,while another 45 healthy subjects served as the control group. The serum levels of PCT,IL-6,hs-CRP and PSP/Reg and lung function were compared between the two groups. The patients in the observation group were followed up for one year,and the occurrence of acute exacerbation of chronic obstructive pulmonary disease was recorded. The serum levels of PCT,IL-6,hs-CRP and PSP/Reg and lung function in patients with acute exacerbation and non-acute exacerbations were compared. The predictive value of serum PCT,IL-6,hs-CRP and PSP/Reg for chronic obstructive pulmonary disease with acute exacerbation was further explored.Results The serum levels of PCT,IL-6,hs-CRP and PSP/Reg in the observation group were significantly higher than those in the control group,and the lung function indexes were significantly lower（ P〈0.05）. During one year follow-up,AECOPD occurred in 93 cases,and the incidence of AECOPD was 87.74%（ 93/106）. The levels of PCT,IL-6,hs-CRP and PSP/Reg in patients with acute exacerbation were significantly higher than those without acute exacerbation,and lung function was significantly lower than among those without acute exacerbation（ P〈0.05）. Serum PCT,IL-6,hs-CRP and PSP/Reg were negatively correlated with lung function in stable COPD,but positively correlated with the incidence of AECOPD（ P〈0.05）. The sensitivity and specificity of combined detection of serum PCT,IL-6,hs-CRP and PSP/Reg in stable COPD were higher than those in single detection. Conclusion There is a negative correlation between serum PCT,IL-6,hs-CRP and PSP/Reg in stable COPD and lung function,but a positive correlation with the incidence of AECOPD. Combined detection of serum PCT,IL-6,hs-CRP and PSP/Reg in patients with stable COPD can improve the prediction of AECOPD.

关 键 词：慢性阻塞性肺疾病 PCT PSP/Reg 肺功能 

分 类 号：R563[医药卫生—呼吸系统]