巨噬细胞游走抑制因子基因多态性与疾病相关性的认识、靶点及意义  

Correlation between gene polymorphism of macrophage migration inhibitory factor and disease susceptibility: recognition,target and significance

作　　者：李静 彭芸[3,4] 宝福凯[2,3,4,5,6] 柳爱华 Li Jing;Peng Yun;Bao Fu-kai;Liu Ai-hua(Suining Municipal Hospital of TCM,Suining 629000,Sichuan Province,China;Department of Microbiology and Immunology;Institute for Tropical Medicine;Yunnan Provincial Key Laboratory for Tropical Infectious Diseases;Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control,Kunming 650500,Yunnan Province,China;yunnan Provincial Demonstration Base of International Science and Technology Cooperation for Tropical Diseases,Kunming 650500,Yunnan Province,China;Department of Biochemistry and Molecular Biology,Kunming Medical University,Kunming 650500,Yunnan Province,China)

机构地区：[1]四川省遂宁市中医院,四川省遂宁市629000 [2]昆明医科大学病原生物学与免疫学系,云南省昆明市650500 [3]昆明医科大学热带医学研究所,云南省昆明市650500 [4]昆明医科大学云南省高校热带传染病重点实验室,云南省昆明市650500 [5]云南省公共卫生与疾病防控协同创新中心,云南省昆明市650500 [6]云南省热带病示范型国际科技合作基地,云南省昆明市650500 [7]昆明医科大学生物化学与分子生物学系,云南省昆明市650500

出　　处：《中国组织工程研究》2018年第28期4574-4579,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(81371835;31560051;81560596);云南省科技厅-昆明医科大学联合基金项目(云南省科技计划项目)(2010CD221;2011FB244;2012FB011;2013FZ057;2014FA011;2014FB001)~~

摘　　要：背景:巨噬细胞游走抑制因子的表达水平在多种疾病中发生改变,其多态性与疾病的易感性、严重程度等相关。文章对巨噬细胞游走抑制因子的基本理化性质、巨噬细胞游走抑制因子基因多态性与疾病易感性的研究进展做一综述。目的:分析巨噬细胞游走抑制因子在各种疾病中的作用机制。方法:应用计算机检索PubMed,SinoMed,CNKI等数据库有关巨噬细胞游走抑制因子与疾病相关的文献,检索词为"MIF,disease,polymorphism;巨噬细胞游走抑制因子,多态性",最终筛选出58篇。结果与结论:无论是自身免疫性疾病、炎性疾病还是在癌症等各系统疾病中均有巨噬细胞游走抑制因子的参与,但巨噬细胞游走抑制因子在各系统疾病中发挥的作用并不相同,如巨噬细胞游走抑制因子既会促进脂肪细胞中肿瘤坏死因子α的分泌产生胰岛素抵抗,又可通过干扰胰岛素介导的内皮细胞一氧化氮释放,参与内皮细胞胰岛素抵抗的发生。巨噬细胞游走抑制因子抵抗糖皮质激素效应且恢复巨噬细胞因子表达和使T淋巴细胞活化,在调节炎症反应的调定点和方向中起着重要作用。因此,了解巨噬细胞游走抑制因子基因的多态与系统疾病存在的互作关系,有利于巨噬细胞游走抑制因子在各系统疾病的基础研究的开展,同时对于发现通过巨噬细胞游走抑制因子作为治疗靶点治疗各种疾病有重要的临床意义。BACKGROUND： Changes in the expression levels of macrophage migration inhibitory factor（MIF） occur in a variety of diseases, and the gene polymorphism of MIF is related to the disease susceptibility and severity. The basic physicochemical properties of MIF, and correlation of MIF gene polymorphism with disease susceptibility are summarized. OBJECTIVE： To analyze the mechanisms of MIF in various diseases. METHODS： Databases of PubMed, Sino Med and CNKI were searched by computer for the articles concerning MIF and diseases using the keywords of ＂MIF, disease, polymorphism＂ in English and Chinese, respectively. Finally 58 eligible articles were included. RESULTS AND CONCLUSION： MIF is involved in various diseases such as autoimmune disease, inflammatory disease and cancer. However, MIF plays different roles in various systemic diseases, for example, MIF promotes the secretion of tumor necrosis factor α in adiposities inducing insulin resistance. It also interferes with insulin-mediated NO release from endothelial cells and participates in the development of insulin resistance in endothelial cells. MIF counteracts glucocorticoid effects, restores macrophage factor expression and activates T lymphocytes, which plays an important role in the regulation of inflammatory response. Therefore, to understand the interaction between MIF gene polymorphism and systemic diseases is conducive to the development of basic research on MIF in various systemic diseases. It is of great significance to find MIF as a therapeutic target for various diseases.

关 键 词：组织工程 巨噬细胞游走抑制因子 多态性 单核苷酸 免疫系统疾病 肿瘤 心血管疾病 MIF 多态性 疾病 易患性 相关性 自身免疫性 炎性疾病 癌症 神经系统性疾病 

分 类 号：R318[医药卫生—生物医学工程]