Wnt信号通路与神经发生、神经退行性变过程中的表述及作用  

Expression and role of wnt signaling pathway in neurogenesis and neurodegeneration

作　　者：王先斌 汤红艳[2] 李兴统 马微[1] 杨金伟[1,3] 代云飞 张同 郭建辉[3] 李力燕[1] Wang Xian-bin;Tang Hong-yan;Li Xing-tong;Ma Wei;Yang Jin-wei;Dai Yun-fei;Zhang Tong;Guo Jian-hui;Li Li-yan(Institute for Neuroscience,Kunming Medical University,Kunming 650500,Yunnan Province,China;Department of Neurosurgery,First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Province,China;Second Department of General Surgery,the First People＇s Hospital of Yunnan Province,Kunming 650032,Yunnan Province,China)

机构地区：[1]昆明医科大学神经科学研究所,云南省昆明市650500 [2]昆明医科大学第一附属医院神经外科,云南省昆明市650032 [3]云南省第一人民医院普外二科,云南省昆明市650032

出　　处：《中国组织工程研究》2018年第28期4587-4592,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(31560295);云南省卫生科技计划项目(2014NS202);昆医联合专项(2015FB098)~~

摘　　要：背景:Wnt信号通路作为一条多环节、多作用位点的开放通路,在神经系统中发挥着非常重要的作用,因此,了解其与神经系统疾病的病理生理机制和治疗的关系有重要意义。目的:分析Wnt信号通路在神经系统疾病中的作用机制。方法:应用计算机检索PubMed、SinoMed等数据库有关Wnt信号通路、神经系统疾病相关的文献,检索词为"Wnt signaling pathway,Nervous system disease,阿尔茨海默病,帕金森病;Wnt信号通路,神经系统疾病",最终筛选出具有代表性的62篇作为研究对象。结果与结论:无论是在阿尔茨海默病、帕金森病、还是在脑血管病等神经系统疾病中均有Wnt信号通路的参与。但Wnt信号通路在各神经系统疾病中发挥的作用并不相同,比如Wnt信号通路功能的缺失使得神经元形成能力下降,直接导致阿尔茨海默病病程加快。Wnt信号通路调控多巴胺能神经元新生、细胞存活、突触发生,从而影响帕金森病发生发展。因此,了解Wnt信号中各配体、受体及基因在神经系统疾病存在的互作关系,有利于Wnt信号通路在神经系统疾病的基础研究的开展,同时对于发现治疗神经系统疾病靶点有重要的临床意义。BACKGROUND： Wnt signaling pathway plays an important role in the nervous system as a multi-link and multi-site open pathway. Therefore, it is important to understand its relationship with the pathophysiology and treatment of neurological diseases. OBJECTIVE： To analyze the mechanism of Wnt signaling pathway in nervous system diseases.METHODS： PubMed and Sino Med were searched for the relevant articles concerning Wnt signaling pathway and nervous system diseases. The key words were ＂Wnt signaling pathway, nervous system disease＂ in English and Chinese, respectively. Finally, 62 pertinent articles were included for result analysis. RESULTS AND CONCLUSION： Wnt signaling pathway is involved in Alzheimer＇s disease, Parkinson＇s disease and cerebrovascular disease. However, its role is different in different neurological diseases. For example, the dysfunction of Wnt signaling pathway leads to the disability of neuronal formation, which accelerates the progression of Alzheimer＇s disease. Besides, Wnt signaling pathway regulates the proliferation of dopaminergic neurons, cell survival and synaptogenesis, thus affecting the development of Parkinson＇s disease. Therefore, understanding the interaction between ligands, receptors and genes in Wnt signaling pathway in nervous system diseases is conducive to the development of Wnt signaling in the basic research of neurological diseases, and is of great significance for searching for the treatment targets of nervous system diseases.

关 键 词：WNT蛋白质类 信号传导 神经系统 组织工程 WNT信号通路 神经系统疾病 神经的发生发育 脑血管病 阿尔茨海默病 帕金森病 组织构建 

分 类 号：R318[医药卫生—生物医学工程]