地衣芽孢杆菌对乙型肝炎肝硬化轻微肝性脑病患者肝功能、血氨和数字连接试验的影响  

Effect of Bacillus Licheniformis on Liver Function, Blood Ammonia and Number Connection Test in Patients with HBV-Related Cirrhosis and Minimal Hepatic Encephalopathy

作　　者：王一飞 王善娟 Wang Yifei;Wang Shanjuan(Department of Gastroenterology,Central Hospital of Jiading District,Shanghai,China 201800)

机构地区：[1]上海市嘉定区中心医院消化内科,上海嘉定201800

出　　处：《中国药业》2018年第17期63-65,共3页China Pharmaceuticals

基　　金：上海市嘉定区医学重点学科资助项目[2017-ZD-01]

摘　　要：目的探讨地衣芽孢杆菌对乙型肝炎肝硬化轻微肝性脑病患者肝功能、血氨和数字连接试验(NCT)的影响。方法选取医院2015年1月至2016年12月收治的乙型肝炎肝硬化轻微肝性脑病患者62例,采用随机数字表法分为对照组及观察组,各31例。对照组患者采用常规治疗,观察组患者在对照组治疗基础上加用地衣芽孢杆菌。结果治疗后,两组患者血清丙氨酸氨基转移酶(ALT)、Child-pugh评分及天门冬酸氨基转移酶(AST)均较治疗前下降,且前两者观察组均明显低于对照组(P<0.05),AST水平明显高于对照组(P<0.05);两组患者血氨(NH3)水平均较治疗前明显下降,且观察组明显低于对照组(P<0.05);两组患者NCT-A、临界闪烁频率(CFF)水平均有明显差异,且观察组均明显优于对照组(P<0.05);两组患者不良反应发生率无明显差异(χ2=1.958,P=0.162>0.05)。结论地衣芽孢杆菌可有效改善乙型肝炎肝硬化轻微肝性脑病患者的肝功能、血氨水平和NCT-A指标,值得推广。Objective To investigate the effect of Bacillus licheniforrnis on liver function, blood ammonia and number connection test（NCT） in patients with hepatitis B virus（HBV）-related cirrhosis and minimal hepatic encephalopathy. Methods Totally 62 patients with HBV- related cirrhosis and minimal hepatic encephalopathy admitted to our hospital from January 2015 to December 2016 were selected and divided into the control group and the observation group according to the random number table method, 31 cases in each group. The control group was treated with routine treatment, on this basis, the observation group was treated with Bacillus licheniformis. Results After treatment, the ALT, Child- pugh scores and AST in the two groups were significantly improved than those before treatment, and the ALT and Child-pugh score in the observation group were significantly lower than those in the control group（P 〈 0. 05）, while the AST in the observation group was significanthy higher than that in the control grouo（P 〈 0.05）.The levels of NH3 in the two groups were decreased than those before treatment, and that in the observation group was significantly lower than that in the control group（P 〈 0.05）. The levels of NCT-A and CFF between the two groups were significantly different, and those in the observation group were significantly better than those in the control group（P 〈 0.05）.There was no significant difference in the incidence rate of adverse reactions between the two groups（x~ = 1. 958, P =0. 162 〉 0.05）. Conclusion Bacillus licheniformis can effectively improve liver function, blood ammonia level and NCT- A indexes in patients with HBV- related cirrhosis and minimal hepatic encephalopathy, which is worthy of promotion.

关 键 词：地衣芽孢杆菌 乙型肝炎肝硬化 轻微肝性脑病 肝功能 血氨 数字连接试验-A 

分 类 号：R969.4[医药卫生—药理学] R975.5[医药卫生—药学]