醋酸甲羟孕酮联合克林霉素磷酸酯治疗产后子宫内膜炎的临床疗效分析  

Clinical Efficacy of Medroxyprogesterone Acetate Combined with Clindamycin Phosphate in the Treatment of Postpartum Endometritis

作　　者：曾强震 ZENG Qiang-zhen(Department of Gynecology and Obstetrics,Macheng People’s Hospital,Maeheng,Hubei Province,438300 Chin)

机构地区：[1]湖北麻城市人民医院妇产科,湖北麻城438300

出　　处：《中外医疗》2018年第18期97-99,共3页China & Foreign Medical Treatment

摘　　要：目的探讨醋酸甲羟孕酮联合克林霉素磷酸酯治疗产后子宫内膜炎的临床疗效。方法方便选取该院2015年8月—2017年7月收治的200例产后子宫内膜炎患者,随机分为观察组、对照组。对照组患者给予克林霉素磷酸酯片,观察组在此基础上给予服用醋酸甲羟孕酮片,治疗2周后,比较两组研究对象C反应蛋白水平,以及白细胞计数恢复时间、体温恢复时间、炎症消失时间、住院时间以及腹痛消失时间。结果经治疗,观察组C反应蛋白水平(1.54±0.95)pg/m L显著低于对照组(5.31±1.43)pg/m L,炎症消失时间(5.86±0.87)d显著短于对照组(8.33±0.51)d,白细胞计数恢复时间、体温恢复时间、住院时间以及腹痛消失时间亦均显著短于对照组,差异有统计学意义(t=4.636、3.563、3.821、5.045、3.204、5.667,P<0.05)。两组患者均未见严重不良反应,观察组与对照组不良反应发生率分别为5.0%(5例)、7.0%(7例),差异无统计学意义(P>0.05)。结论醋酸甲羟孕酮联合克林霉素磷酸酯治疗产后子宫内膜炎疗效较好,患者恢复较快,值得推广应用。Objective This paper tries to investigate the clinical efficacy of medroxyprogesterone acetate combined with clindamycin phosphate in the treatment of postpartum endometritis. Methods A total of 200 patients with postpartum endometritis admitted to this hospital from August 2015 to July 2017 were convenient selected and randomly divided into observation group and control group. Patients in the control group received clindamycin phosphate tablets. The observation group was given medroxyprogesterone acetate tablets on this basis. After 2 weeks of treatment, the levels of C-reactive protein in the subjects of the two groups were compared, and the recovery time and body temperature of the white blood cells,disappearance of inflammation, hospital stay, and disappearance of abdominal pain were compared. Results After treatment,the C-reactive protein level in the observation group（1.54±0.95）pg/m L was significantly lower than that in the control group（5.31±1.43）pg/m L, and the disappearance time of inflammation（5.86±0.87）d was significantly shorter than that in the control group（8.33±0.51）d, WBC count recovery time, body temperature recovery time, length of stay and abdominal pain disappearance were also significantly shorter than the control group, with significant difference（t =4.636, 3.563, 3.821, 5.045,3.204, 5.667, P〈0.05）. There were no serious adverse reactions in both groups. The incidence of adverse reactions in the observation group and the control group was 5.0%（5 cases） and 7.0%（7 cases）, respectively, with no significant difference（P〉0.05）. Conclusion The efficacy of medroxyprogesterone acetate combined with clindamycin phosphate in the treatment of postpartum endometritis is better, and the patient recovers quickly and is worthy of popularization and application.

关 键 词：醋酸甲羟孕酮 克林霉素磷酸酯 子宫内膜炎 

分 类 号：R5[医药卫生—内科学]