血清降钙素原及C反应蛋白检测在老年肺炎抗菌药物治疗中的价值  

Clinical Application of Serum Procalcitonin and C-reactive Protein in the Treatment of Senile Pneumonia

作　　者：钱晓娟[1] 周新明[1] 鲁文育 胡风涛[1] 袁雯婷 QIAN Xiao-juan, ZHOU Xin-ming,LU Wen-yu, HU Feng-tao,YUAN Wen-ting(Department of Clinical Laboratory Huang Mei People＇s Hospital,Huanggang 435500,China)

机构地区：[1]湖北省黄梅县人民医院检验科,黄冈435500

出　　处：《微循环学杂志》2018年第3期43-46,共4页Chinese Journal of Microcirculation

摘　　要：目的:探讨血清降钙素原(PCT)、C-反应蛋白(CRP)检测在指导老年肺炎抗菌治疗中的作用。方法:2015-05—2016-03本院呼吸内科收治的老年肺炎患者91例,入院时PCT>0.50ng/ml,CRP>6.00ng/ml,随机分为观察组(n=44)和对照组(n=47),两组患者均根据抗菌药物的临床应用原则进行治疗。治疗过程中,对照组依据患者体征、临床表现等变化,调整或停止抗生素的应用;观察组患者则根据患者血清PCT和CRP的水平并结合临床表现调整或停止抗生素的治疗。比较两组患者住院时间、住院费用和抗生素使用时间的差异。结果:治疗前两组患者PCT、CRP、白细胞计数(WBC)及血沉(ESR)水平差异无统计学意义,治疗后,观察组患者PCT、CRP、WBC和ESR均明显低于对照组(P<0.05);观察组患者抗生素使用时间明显短于对照组(P<0.05);观察组老年肺炎患者PCT、CRP、WBC与抗生素使用时间长短均呈显著正相关(r=0.684、0.720、0.430,P<0.01)。结论:血清PCT、CRP检测指导老年肺炎抗菌治疗可缩短抗生素使用时间,值得临床推广应用。Objective：To investigate the role of serum procalcitonin（PCT）and C-reactive protein（CRP）in the antibacterial treatment of senile pneumonia.Method：91 cases of respiratory medicine in our hospital 2015-05—2016-03 from pneumonia in the elderly patients,were randomly divided into observation group（n=44）and control group（n=47）,control group patients according to the clinical judgment of the clinicians given antibiotic treatment,patients in the observation group according to the body PCT and CRP level given antibiotic treatment.Results：Serum PCT,CRP,WBC and ESK in the observation group patients were significantly lower than the control group（P〈0.05）.Patients in the observation group use of antibiotics was significantly shorter than the control group（P〈0.05）.Serum PCT,CRP,WBC and duration of antibiotic use duration were significantly correlated（r=0.684,0.720,0.430 P〈0.01）.Conclusion：The detection of serum PCT and CRP plays an important role in the treatment of pneumonia in elderly patients.It is worth popularizing in clinical practice.

关 键 词：血清降钙素 血清C-反应蛋白 老年肺炎患者 

分 类 号：R446.11[医药卫生—诊断学] R563.1[医药卫生—临床医学]