高盐饮食对H.pylori感染的MGs胃黏膜TFF2表达水平的影响  

Effect of high-salt diet on the expression of TFF2 in gastric mucosa of H.pylori-infected MGs

作　　者：陈雪 胡又 谢颖 王莹[1] Xue Chen;You Hu;Ying Xie;Ying Wang(Huanghe North Avenue,Shenyang,Liaoning,Shenyang 110034,Liaoning,China)

机构地区：[1]沈阳医学院病理教研室,辽宁沈阳110034

出　　处：《医学食疗与健康》2018年第3期7-8,共2页Medical Diet and Health

基　　金：本研究受2017年辽宁省科学事业公益研究基金项目（20170025）及2017年度辽宁省教育评价协会第二届教学改革与教育质量评价研究项目（PJHYYB17189）资助

摘　　要：目的明确幽门螺杆菌（H.pylori）感染和高盐饮食对蒙古沙土鼠胃黏膜Trefoil factor 2（TFF2）表达的影响.方法：用80只MGs建立H.pylori 感染的胃疾病模型.免疫组化检测TFF2的表达. 结果：成功建立H.pylori感染的MGs模型,免疫组化结果显示,H. pylori＋高盐饮食组中,25% （4/16） 的 MGs为 TFF2高表达,明显低于 H. pylori组61%（11/18）.结论：高盐饮食会降低H.pylori诱导的MGs胃黏膜TFF2的表达.Objective This study aimed to elucidate the effect of H. pylori and high-salt diet on TFF2 expression of Mongolian gerbils （MGs） gastric mucosa. Materials and Methods： Altogether 80 MGs were used to build the model for gastric diseases. Immunohistochemical staining was adopted to detect the TFF2 expression. Results： H. pylori infected MGs model was built successfully. According to the immunohistochemical staining results, 25% （4/16） of H. pylori infected MGs with high-salt diet showed high TFF2 expression, which was significantly lower than H. pylori group 61% （11/18）. Conclusion： High-salt diet could decrease TFF2 expression of MGs gastric mucosa induced by H. pylori infection.

关 键 词：TFF2 幽门螺杆菌 高盐饮食 胃疾病 蒙古沙土鼠 

分 类 号：R5[医药卫生—内科学]