舒利迭联合思力华治疗稳定期COPD患者肺功能的临床效果  

Seretide combining spiriva for patients with stable chronic obstructive pulmonary disease

作　　者：翟瑞玲 胡国新 何梦璋[3] Zhai Ruiling;Hu Guoxin;He Mengzhang(Department of Pharmac;Department of Internal Medicine,Gaoyao District Hospital of Traditional Chinese Medicine,Zhaoqing 526100,China;Department of Respiratory Medicine,First Hospital,Guangzhou Medical University,Guangzhou 510000,Chin)

机构地区：[1]肇庆市高要区中医院药剂科,526100 [2]肇庆市高要区中医院内一科,526100 [3]广州医科大学附属第一医院呼吸内科,510000

出　　处：《国际医药卫生导报》2018年第16期2537-2540,共4页International Medicine and Health Guidance News

摘　　要：目的 观察评价舒利迭联合思力华治疗稳定期慢性阻塞性肺疾病（COPD）患者肺功能的临床效果.方法 将收治的稳定期COPD患者86例,按照数字法随机分为两组;对照组43例给予舒利迭治疗,观察组43例在对照组基础上加用思力华治疗,并比较两组的临床效果.结果 观察组总有效率为97.67％,显著高于对照组的86.05％（x2=3.888,P=0.049）;两组治疗后PaO2较治疗前均明显升高（均P＜ 0.05）,而PaCO2较治疗前显著下降（均P＜0.05）,观察组PaO2明显高于对照组（t=11.673,P＜ 0.05）,观察组PaCO2明显低于对照组（t=10.684,P＜0.05）;两组治疗后FEV1、FVC、FEV1/FVC均显著高于治疗前（均P＜ 0.05）,观察组FEV1、FVC、FEV1/FVC均高于对照组（t=5.282、8.173、4.973,均P=O.000）.结论 舒利迭联合思力华治疗COPD患者能够有效地提高临床疗效,显著地改善临床症状及肺功能,值得临床大力推广.Objective To evaluate the clinical effect of seretide combining spiriva in the treatment of patients with stable chronic obstructive pulmonary disease （COPD）.Methods 86 patients with stable COPD were enrolled and randomly divided into a control group and an observation group,43 cases for each group.The control group were treated with seretide,and observation group with seretide and spiriva.The clinical effects of the two groups were compared.Results The total effective rate of the observation group was 97.67%,which was significantly higher than that of the control group （86.05%） （x 2=3.887 9,P=0.000 0）.PaO2 was significantly higher in both groups after treatment （P〈0.05）.The PaCO2 was significantly lower and the PaO2 was significantly higher after than before the treatment in both groups （P 〈 0.05）,and were so in the observation group than in the control group after the treatment （t=11.673 and 10.684,P 〈 0.05）.The FEV1,FVC,and FEV1/FVC were significantly higher after than before the treatment in both groups （P〈0.05）,and were so in the observation group than in the control group after the treatment （t=5.281 6,8.172 9,and 4.972 3,P=0.000 0）.Conclusion Seretide combining spiriva for patients with stable chronic obstructive pulmonary disease is effective and can improve their symptoms and pulmonary function,so it is worth being clinically generalized.

关 键 词：慢性阻塞性肺疾病 舒利迭 思力华 啼功能 

分 类 号：R563.9[医药卫生—呼吸系统]