乙肝患者HBV-DNA载量与乙肝血清标志物及前S1抗原和肝功能指标的临床研究  

Clinical study on HBV-DNA load and hepatitis B serum markers, pre-S1 antigen, and liver function in hepatitis B patients

作　　者：林坤培 黄而君 甘保波 胡金燕 Lin Kunpei;Huang Loun;Gan Baobo;Hu Jinyan(Clinical Lab,Luoding People＇s Hospital,Luoding 527200,China;Infection Dept.,Luoding People＇s Hospital,Luoding 527200,China)

机构地区：[1]罗定市人民医院检验科,527200 [2]罗定市人民医院感染科,527200

出　　处：《国际医药卫生导报》2018年第15期2252-2254,共3页International Medicine and Health Guidance News

基　　金：云浮市医药卫生科研课题（2015842）

摘　　要：目的观察分析乙肝患者HBV—DNA载量与乙肝血清标志物、乙肝前sl抗原及肝功能指标之间的关系。方法选取536例乙型病毒性肝炎患者作为研究对象，分别检测HBV—DNA载量、血清学标记物、前sl抗原及ALT、AST，并对结果进行相关性分析。结果大三阳组患者HBV—DNA阳性率（92．8％）高于小三阳组（55．9％）和1，5组（46．7％），差异有统计学意义（P〈0．05）。大三阳组HBV—DNA病毒载量处于较高复制水平，高于小三阳组、1，5组，差异有统计学意义（P〈0．05）。536例乙肝患者HBV—DNA阳性率为71．5％，Pre—S1阳性率为64．2％，HBV—DNA阳性者的Pre—S1阳性率（78．9％）明显高于HBV—DNA阴性者（27．5％），差异有统计学意义（P〈0．05），Pre—S1的阳性率随HBV—DNA载量升高而增高，两者具有显著正相关。HBV—DNA阳性者ALT、AST水平明显高于HBV—DNA阴性者，差异有统计学意义（P〈0．05），ALT、AST水平随HBV—DNA载量升高而增高，两者具有显著正相关。结论不同乙肝类型患者HBV—DNA载量及阳性率存在差异，HBV—DNA载量与Pre—S1、ALT、AST呈正相关。Objective To analyze the relationship between HBV-DNA load and hepatitis B serum markers, hepatitis B pre-S1 antigen, and liver function indicators in patients with hepatitis B. Methods A total of 536 patients with viral hepatitis B were selected as the study subjects. The HBV-DNA load, serological markers, pre-S1 antigen, ALT, AST were detected and the results were analyzed. Results The positive rate of HBV-DNA in Dasanyang group was 92.8%, higher than those in Xiaosanyang group （55.9%） and 1,5 group （46.7%）, with statistically significant differences （P〈0.05）. The viral load of HBV-DNA in the Dasanyang group was higher than those in the Xiaosmyang group and the 1,5 group, with statistically significant differences （P〈0.05）. The positive rate of HBV-DNA in 536 patients with hepatitis B was 71.5%, the positive rate of Pre-S1 was 64.2%, the positive rate of Pre-S1 in HBV-DNA positive group was significantly higher than that in HBV-DNA negative group （78.9% vs. 27.5%）, with statistically significant difference （P〈0.05）, the positive rate of Pre-S1 increased with the increase of HBV-DNA load, and there was a significant positive correlation between them. The levels of ALT and AST in HBV-DNA positive group were significantly higher than those in HBV-DNA negative group, with statistically significant differences （P〈0.05）, the levels of ALT and AST increased with the increase of HBV-DNA load, and there was a significant positive correlation between them. Conclusion There are differences in HBV-DNA load and positive rate among different types of hepatitis B patients, and HBV-DNA load is positively correlated with Pre-S1, ALT, and AST.

关 键 词：乙型肝炎 HBV—DNA 乙肝前S1抗原 血清标志物 肝功能指标 相关性 

分 类 号：R512.62[医药卫生—内科学] R446[医药卫生—临床医学]