常频机械通气与经鼻间歇正压通气治疗早产儿呼吸窘迫综合征的疗效分析  

Therapeutic effect of constant frequency mechanical ventilation and nasal intermittent positive pressure ventilation on respiratory distress syndrome in preterm infants

作　　者：傅光华 谭清 梁美嫦 余韶卫[2] Fu Guanghua;Tan Qing;Liang Meichang;Yu Shaowei(Department of Pediatrics,Luoding Maternal and Child Health Hospital,funfu 527200,China;Department of Pediatrics,Fourth Affiliated Hospital of Jinan University School of Medicine,Guangzhou Red Cross Hospital,Guangzhou 510613,China)

机构地区：[1]罗定市妇幼保健院儿科,527200 [2]暨南大学医学院第四附属医院广州市红十字会医院儿科,510613

出　　处：《国际医药卫生导报》2018年第15期2321-2324,共4页International Medicine and Health Guidance News

摘　　要：目的观察评价常频机械通气（CMV）与经鼻间歇正压通气（NIPPV）治疗早产儿呼吸窘迫综合征（RDS）的临床效果。方法选择2016年8月至2018年2月期间罗定市妇幼保健院收治的早产儿呼吸窘迫综合征98例，并随机分为两组，对照组49例给予CMV治疗；观察组49例给予NIPPV治疗，并比较两组的临床效果。结果观察组总有效率明显高于对照组（95．92％比73．47％，χ^2=9．5245，P=0．0000）；两组PaO2、SaO2均高于治疗前，而PaCO2低于治疗前（P〈0．05），且观察组Pa0，高于对照组（t=1．7249，P〈0．05），PaC02低于对照组（t=4．5703，P〈0．05），但两组SaO2治疗后比较差异无统计学意义（t=0．3419，P〉0．05）；观察组总并发症发生率显著低于对照组（14．29％比59．18％，χ^2=21．2509，P〈0．05）。结论NIPPV治疗RDS提高了临床疗效，显著地改善早产儿的血气指标，缓解临床症状，提高患儿的通气功能，降低并发症发生率。Objective To observe and evaluate the clinical effects of constant frequency mechanical ventilation （CMV） and nasal intermittent positive pressure ventilation （NIPPV） in the treatment of respiratory distress syndrome （RDS） in preterm infants. Methods 98 preterm infants with respiratory distress syndrome in Luoding Maternal and Child Health Hospital from August 2016 to February 2018 were divided into two groups randomly. Forty-nine patients in the control group were treated by constant frequency mechanical ventilation （CMV）, 49 patients in the observation group were treated by nasal intermittent positive pressure ventilation （NIPPV）. Compared the clinical efficacy of the two groups. Results The total effective rate was 95.92% in the observation group, which was significantly higher than 73.47% in the control group （χ^2=9.524 5, P=0.000 0）. PaO2 and SaO2 in both two groups after treatment were higher than those before treatment, while PaCO2 was lower than that before treatment （P〈0.05）; PaO2 in the observation group was higher than that in the control group （t=-1.724 9, P〈0.05）, PaCO2 was lower than that in the control group （t=-4.570 3, P〈0.05）, but there was no statistically significant difference in SaO2 between the two groups after treatment （t=-0.341 9, P〉0.05）. The overall incidence of complications in the observation group was 14.29%, which was significmatly lower than that in the control group （59.18%） （χ^2=21.250 9, P〈0.05）. Conclusion Nasal intermittent positive pressure ventilation （NIPPV） improves the clinical efficacy of preterm infants with respirato .ry distress syndrome （RDS）, significantly improves blood gas indexes in preterm infants, relieves clinical symptoms, improves ventilatory function, and reduces the incidence of complications.

关 键 词：早产儿 呼吸窘迫综合征 常频机械通气 经鼻间歇正压通气 

分 类 号：R722.6[医药卫生—儿科]