IgA/C3在IgA肾病中的辅助诊断价值分析  

The auxiliary diagnosis value of IgA/C3 in IgA nephropathy

作　　者：张少鑫 郑自力[1] 王云良[2] ZHANG Shaoxin;ZHENG Zili;WANG Yunliang(Department of Urology,Jinjiang Municipal Hospital,Fujian,Jinjiang 362200,China)

机构地区：[1]福建省晋江市医院肾内科,362200 [2]福建省晋江市医院检验科,362200

出　　处：《河北医药》2018年第15期2341-2343,共3页Hebei Medical Journal

基　　金：福建省自然科学基金项目(编号:2014J010565)

摘　　要：目的探究IgA/C3在IgA肾病中的辅助诊断价值分析。方法选择2014年5月至2015年7月接受治疗的肾病患者85例为本次研究对象,按病原性分为IgA组和非IgA组,比较2组患者IgA、C3和IgA/C3 3组指标;同时将IgA患者按Lee’s肾病等级分为3组,分别比较每组IgA、C3和IgA/C3指标;另外将IgA与IgA/C3作为IgA肾病诊断效能比较。结果 IgA组患者IgA[(2.80±1.01)g/L、(1.79±0.31)g/L]和IgA/C3[(3.09±1.31)、(1.26±0.40)]均高于非IgA组(P<0.05);而C3低于非IgA组[(0.91±0.30)、(1.42±0.28)](P<0.05)。按Lee’s肾病等级分为3组的IgA患者的IgA和IgA/C3的表达均相差较小,差异无统计学意义(P>0.05);IgA与IgA/C3作为IgA肾病诊断效能比较中,IgA/C3的AUC(0.952、0.807)和敏感性(92%、71%)均高于IgA(P<0.05)。结论血清IgA、补体C3的比值,在判别非IgA和IgA患者的过程中可以起到重要的辅助作用,但在IgA患者的诊断中,难以有效的预测价值以及判断价值,还需要进行深入研究找出其与IgA肾病的内在联系。Objective To investigate the auxiliary diagnosis value of IgA/C3 in IgA nephropathy. Methods A total of 85 patients with nephropathy who were treated in our hospital from May 2014 to July 2015 were enrolled in the study.According to pathogenicity,these patients were sdivided into IgA group and non-IgA group. The IgA,C3 and IgA/C3 were observed and compared between the two groups. Moreover according to Lee＇s nephropathy grade,these patients were divided into three group,and IgA,C3 and IgA/C3 were observed and compared. In addition the diagnostic efficacy for IgA nephropathy was evaluated by means of IgA and IgA/C3. Results The levels of IgA and IgA/C3 in IgA group were significantly higher than those in non-IgA group,IgA [（2. 80 ± 1. 01） g/L vs（1. 79 ± 0. 31） g/L] and IgA/C3 [（3. 09 ± 1. 31） vs（1. 26 ±0. 40） ]（P〈 0. 05）. However the levels of C3 in IgA group were significantly lower than those in non-IgA group [（0. 91 ±0. 30） vs（1. 42 ± 0. 28） ]（P〈 0. 05）. There were no significant differences in the expressin levels of IgA and IgA/C3 among the three groups with different Lee＇s nephropathy grades（P〉 0. 05）. Besides the AUC of IgA/C3 and sensitivity of IgA/C3 as diagnostic efficacy for IgA nephropathy were significantly higher than those of IgA（0. 952,0. 807） and（92%,71%）（P〈 0. 05）. Conclusion The serum levels of IgA and complement C3 ratio play an important role in distinguishing non-IgA patients from IgA patients,however,it is difficult to predict nephropathy in diagnosis of nephropathy,thus,it is necessary to investigate deeply to find out its intrinsic correlation with IgA nephropathy.

关 键 词：IGA肾病 IGA C3 IgA/C3 

分 类 号：R726.926[医药卫生—儿科]