超声波数域衰减系数评估早期肝纤维化在体实验初步研究  

Pilot study of wave-number domain attenuation coefficient (W-Ac) for evaluation early liver fibrosis in vivo experiment

作　　者：丁腾云 邱文倩[1] 王亚丹[3] 张嘉靖 郑驰超[3] 张超学[1] Ding Tengyun;Qiu Wenqian;Wang Yadan(Dept of Ultrasound,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Dept of Ultrasound,Anqing Hospital of Anhui Medical University,Anqing 246003;Dept of Biomedical Engineering,Hefei University of Technology,Hefei 230009)

机构地区：[1]安徽医科大学第一附属医院超声科,合肥230022 [2]安徽医科大学附属安庆医院(安庆市立医院)超声科,安庆246003 [3]合肥工业大学生物医学工程系,合肥230009

出　　处：《安徽医科大学学报》2018年第9期1469-1472,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1708085MH205)

摘　　要：探索超声波数域衰减系数评估早期肝纤维化在体实验的可行性。以肝脏近场区域为参照对象,以其远场肝脏为感兴趣区域,采集36例参与者肝脏波束形成后射频信号(PRF)数据及肝脏穿刺活检病理,采用波数域衰减系数计算方法对PRF信号进行处理,并与肝纤维化分级对照分析。36例参与者病理分期分为S0~S2期,其衰减系数分别为(0.090 4±0.018 7)、(0.126 7±0.025 1)、(0.141 1±0.031 0),随着肝纤维程度增加,肝脏波数域衰减系数呈增高趋势,与肝纤维化分期具有较好相关性。波数域衰减系数在早期肝纤维化不同分期中有显著差异,该方法具有在体无创评估肝纤维化的潜能。In this study,we try to evaluate the possibility of wave-number domain attenuation coefficient（ WAc） in quantitatively differentiating early stage of liver fibrosis in vivo. In our method,the echo from near field liver tissue was selected as reference signal,the echo from far field a certain depth is selected as ROI,and the W-Ac of ROI was calculated based on its post-beam forming radio frequency（ PRF） signals. 36 patients with HBV were performed ultrasound examination to acquire PRF data,and all patients were performed liver biopsy to estimate liver fibrosis stages. The relationship was analyzed. The mean of W-Ac in S0-S2 groups was（ 0. 090 4 ± 0. 018 7）,（ 0. 126 7 ± 0. 025 1）,（ 0. 141 1 ± 0. 031 0）,respectively. W-Ac are significantly different in different phases of early hepatic fibrosis,which has the potential of non-invasive assessment of hepatic fibrosis in vivo.

关 键 词：超声 射频信号 衰减系数 肝纤维化 

分 类 号：R445.1[医药卫生—影像医学与核医学]