血小板参数在判断慢性丙型肝炎RNA水平中的价值  

The value of platelet parameters in determining the level of chronic hepatitis C RNA

作　　者：张夏[1] 杜丹丹 翟志敏[3] 郭进京[1] Zhang Xia;Du Dandan;Zhai Zhimin(Dept of Laboratory Medicine,Fuyang People＇ s Hospital,Fuyang 236000;Dept of Cardiology,The Second People＇ s Hospital of Fuyang City,Fuyang 236000;Dept of Hematology,The Second Hospital of Anhui Medical University,Hefei 230601)

机构地区：[1]阜阳市人民医院检验科,阜阳236000 [2]阜阳市第二人民医院心内科,阜阳236000 [3]安徽医科大学第二附属医院血液内科,合肥230601

出　　处：《安徽医科大学学报》2018年第8期1307-1310,共4页Acta Universitatis Medicinalis Anhui

基　　金：教育部高等学校博士学科点专项科研基金(编号:20103420110001)

摘　　要：以78例丙肝抗体阳性患者为研究对象,分析血小板计数(PLT),血小板分布宽度(PDW),平均血小板体积(MPV),血小板压积(PCT)及丙肝RNA载量。HCV-RNA阳性组PLT和PCT减低,PDW和MPV增高(P<0.001);RNA阳性组中低HCV-RNA载量组有更高的PLT和PCT,更低的PDW和MPV(P<0.05);HCV-RNA的高低和各参数间相关性分析显示HCV-RNA载量和MPV呈正相关性(r=0.306,P=0.026),和PLT(r=0.493,P<0.001),PCT(r=0.444,P=0.001)呈负相关性,和PDW相关性分析无统计学意义(r=0.258,P=0.063)。血小板参数能辅助判断丙肝病毒复制的严重程度。The blood platelet count（ PLT）,platelet distribution width（ PDW）,mean platelet volume（ MPV）,platelet volume（ PCT） and hepatitis C RNA load were analyzed in 78 cases of hepatitis C antibody positive patients.Compared with HCV-RNA negative group,HCV-RNA positive group of PLT and PCT decreased significantly,PDW and MPV were significantly increased（ P〈0. 001）; low HCV-RNA load group had higher PLT,PCT and lower PDW,MPV（ P〈0. 05）; HCV-RNA load was positively correlated with MPV（ r = 0. 306,P = 0. 026）,and negatively correlated with PLT（ r = 0. 493,P = 0. 000） and PCT（ r = 0. 444,P = 0. 001）,the correlation analysis between PDW and HCV-RNA was not statistically significant（ r = 0. 258,P = 0. 063）. Monitoring platelet parameters in patients with hepatitis c can help determine the severity of virus replication.

关 键 词：丙型肝炎 血小板参数 病毒载量 

分 类 号：R512.63[医药卫生—内科学]