用于体外循环装置的材料涂层技术综述与展望  

The Review and Prospect of Cadiopulmonary Bypass Coating Materials

作　　者：姜涛 王瑞彬 霍枫[2] JIANG Tao;WANG Ruibin;HUO Feng(Guangdong Shunde Industrial Design Institute（Guangdong Shunde Innovative Design Institute）,Foshan 528311;Department of Hepatobiliary Surgery,General Hospital of Guangzhou Military Command of PLA,Guangzhou 510010)

机构地区：[1]广东顺德工业设计研究院(广东顺德创新设计研究院),佛山528311 [2]广州军区广州总医院肝胆外科,广州510010

出　　处：《材料导报》2018年第13期2304-2310,2328,共8页Materials Reports

基　　金：广东省科技计划项目(2012A030400023)

摘　　要：近几十年来,血液透析、心肺分流术、骨科、血管和重建手术等医学技术的不断进步促进了直接与生物组织接触的人工材料的迅速发展。由于任何外物与血液接触都会导致血液产生各种应急反应,最终引发凝血,导致医疗器械的闭塞和栓塞,这极大限制了材料在医学领域的应用。因此,提高体外循环中材料的生物相容性,特别是血液相容性,是解决问题的关键。目前,表面涂层技术是改善材料表面生物相容性最有效、应用最广泛的技术。本文主要综述了提高材料血液相容性的三种主要途径:构建生物材料惰性表面、材料表面仿生化、负载生物活性物质。同时介绍了诸如白蛋白、聚氧化乙烯、聚己酸内酯-聚二甲硅氧烷-聚己酸内酯、聚2-丙烯酸-2-甲氧基乙酯、磷酰胆碱、糖胺多糖、肝素、水蛭素、双嘧达莫等多种表面涂层技术及其临床应用,并对未来提高体外循环系统血液相容性的新方向提出展望。During the past several decades,the progress in techniques such as extracorporeal procedures including haemodialysis,cardiopulmonary bypass,as well as orthopedic,vascular and reconstructive surgery promoted the use of artificial materials in contact with living tissue dramatically.The evolution has highlighted the problems of biocompatibility.In the case of blood contact with any foreign materials induces activation of several host response defense mechanisms such as haemostatic mechanism,with consequences as thrombus formation,occlusion of medical device and embolization,which greatly limits the application of materials in medicine.Therefore,improving the biocompatibility of materials in cadiopulmonary Bypass system,especially the hemocompatibility,is the key to solve this problem.At present,the most effective and widely used technique for improving the biocompatibility of materials is surface coating technology.This paper reviews three main ways to improve the hemocompatibility of materials：build biological inert surface,bionic surface,and load bioactive substances,at the same time introduce several surface coating technologies and their clinical application,such as albumin,polyethylene oxide,SMA,PEMA,phosphorylcholine,glycosaminoglycan,heparin,hirudin,dipyridamole,and others.In the end,give a prospect of improving the hemocompatibility of cadiopulmonary bypass system.

关 键 词：涂层 体外循环 生物相容性 血液相容性 抗凝血 肝素 

分 类 号：R318.08[医药卫生—生物医学工程]