人类获得性免疫缺陷综合征合并播散性马尔尼菲青霉菌病和噬血细胞综合征一例并文献复习  

A case of acquired immune deficiency syndrome complicated with disseminated penicilliosis marneffei and hemophagocytic syndrome and the literature review

作　　者：王中涛 熊勇[1] 邓莉平[1] 田素芳[2] 陈飞[3] Wang Zhongtao;Xiong Yong;Deng Liping;Tian Sufang;Chen Fei(Department of Infectious Diseases;Department of Hematology;Department of Pathology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院感染科,武汉市430071 [2]武汉大学中南医院病理科,武汉市430071 [3]武汉大学中南医院血液内科,武汉市430071

出　　处：《中华实验和临床感染病杂志（电子版）》2018年第3期307-312,共6页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的提高对人类获得性免疫缺陷综合征(AIDS)合并播散性马尔尼菲青霉菌病(PSM)、噬血细胞综合征(HPS)和组织细胞坏死性淋巴结炎(HNL)的认识。方法分析1例AIDS合并播散性PSM、HPS以及HNL(疑诊)的诊疗过程,并结合相关文献进行复习。结果 1例43岁男性AIDS合并播散性PSM、HPS以及HNL(疑诊)患者,给予综合抗感染、抗炎(小剂量地塞米松)、护肝及对症支持治疗后,患者体温恢复正常,病情稳定出院。结论早期诊断及治疗PSM、HPS、HNL是降低患者病死率及改善预后的关键。Objective To enhance the awareness on acquired immune deficiency syndrome（AIDS） complicated with disseminated penicilliosis marneffei（PSM）, hemophagocytic syndrome（HPS） and histocytic necrotizing lymphadenitis（HNL）. Methods The process of diagnosis and treatment of one AIDS patients complicated with disseminated PSM, HPS and HNL（suspected） was analyzed. The relevant literatures were reviewed. Results One 43 years old man with AIDS complicated with disseminated PSM, HPS and HNL（suspected） was enrolled and treated by comprehensive anti-infection, anti-inflammatory（low dose dexamethasone）, liver protection and symptomatic support. The patient recovered normal temperature and discharged in stable condition after treatment. Conclusions Early diagnosis and treatment of PSM, HPS and HNL are the keys to reduce the mortality and improve the prognosis for patients.

关 键 词：人类获得性免疫缺陷综合征 播散性马尔尼菲青霉菌病 噬血细胞综合征 组织细胞坏死性淋巴结炎 

分 类 号：R512.91[医药卫生—内科学]