320排CT评价磨玻璃影相对体积对百草枯所致肺损伤的诊断价值  

Diagnostic Value of Relative Volume of Ground Glass Opacities in Lungs Injury by 320-row CT in Paraquat Intoxication

作　　者：孙荣庆 向述天[1] 苏云杉[1] 岳梨蓉[1] 何茜[1] 彭聪 SUN Rong-qing;XIANG Shu-tian;SU Yun-shan;YUE Li-rong;HE Qian;PENG Cong(Dept.of Radiology,The Fourth Affiliated Hospital,Kunming Medical University,Kunming Yunnan 650021,China)

机构地区：[1]昆明医科大学第四附属医院放射科,云南昆明650021

出　　处：《昆明医科大学学报》2018年第7期15-19,共5页Journal of Kunming Medical University

基　　金：昆明医科大学研究生创新基金资助项目(2017S145)

摘　　要：目的应用320排CT测定肺部磨玻璃影(ground glass opacity,GGO)相对体积评估家兔百草枯中毒后肺损伤程度.方法 48只健康家兔随机分为4组,以梯度浓度为25、35、45 mg/kg百草枯及等剂量生理盐水灌胃处理,于中毒后第1、7、14及28 d行320排CT检查,行GGO相对体积半定量分析,并于上述时间点每组随机处死1只家兔取肺组织行病理观察.结果 3组实验组与正常对照组比较,GGO相对体积在各时间段均明显大于对照组(P<0.05);3组中毒组家兔之间两两比较,不同药物浓度作用时存在剂量依赖性(P<0.05),即GGO相对体积随药物剂量增加而增加;光镜下中毒组家兔肺组织表现为不同程度炎性细胞浸润,局灶性充血,肺泡间隔增宽,肺泡萎陷,部分肺泡腔闭塞,上述病理改变随时间延长加重.结论 320排CT测定GGO相对体积可以较好量化评价百草枯所致肺损伤,为临床评价百草枯所致肺损伤提供客观依据.Objective To assess the diagnostic value of the relative volume of ground glass opacities（GGO） in lungs injury by 320-row CT in paraquat intoxication.Methods A total of 48 healthy rabbits were randomly divided into four groups： one control group and three experimental groups by gavage treating with the concentration of25,35,45 mg/kg paraquat and equal dose of physiological saline.320-row CT examination were performed on the1 st, 7 th, 14 th and 28 th day after poisoning. Semi-quantitative analysis of the relative volume of GGO was conducted. One rabbit from each group were randomly sacrificed to obtain the lung tissue for pathological examinations at each time point.Re s ults Compared with the control group, the relative volumes of GGO in the three experimental groups were significantly greater than that in the control group at each time point（P〈0.05）.Significant dose-dependence at different drug concentrationsin in the three experimental groups were found througy multiple comparison（P〈0.05）. The relative volume of GGO increased with the increasing of drug dose. The lung tissues of poisoned rabbits under light microscope showed different degrees of inflammatory cell infiltration, focal hyperemia, widened alveolar septum, alveolar collapse, and partial alveolar cavity occlusion,and all the above pathological changes worsened with time.Conclus ion 320 row CT determination of relative volume of GGO can better quantify the paraquat-induced lung injury, which can provide an objective basis for clinical evaluation.

关 键 词：320排CT 百草枯 肺损伤 磨玻璃影 相对体积 

分 类 号：R814.42[医药卫生—影像医学与核医学]