米非司酮预防成年女性药物流产后并发妇科炎症的临床疗效研究  

Research on Clinical Curative Effect of Mifepristone in Preventing the Gynecological Inflammation of Adult Females after the Drug Abortion

作　　者：贾中艳[1] JIA Zhong-yan(Department of Medical Insurance,Kashi Region First People＇ s Hospital,Kashi,Xinjiang,844000 China)

机构地区：[1]喀什地区第一人民医院医保科,新疆喀什844000

出　　处：《系统医学》2018年第10期103-105,共3页Systems Medicine

摘　　要：目的探讨米非司酮预防成年女性药物流产后并发妇科炎症的临床疗效。方法选取该院2015年1月—2017年1月收治的80例药物流产成年女性为研究对象,将本组患者随机分为两组,对照组40例患者给予米索前列醇和米非司酮进行药物流产,观察组40例患者则在米索前列醇和米非司酮进行药物流产后,药物流产后2周给予药物流产后2周给予继续服用米非司酮进行早期药物干预,对比两组患者药物流产前后HCG水平以及妇科炎症发病率。妇科炎症包括宫颈炎、阴道出血、阴道炎、颈柱状上皮异位等。结果两组患者药物流产前HCG水平分别为(13 676.01±3 387.56)IU/L、(13 977.93±3 311.22)IU/L,对比差异无统计学意义(t=0.403 1,P>0.05);药物流产后2周两组患者HCG水平分别为(66.98±12.38)IU/L、(68.05±11.76)IU/L,均较药物流产前显著下降,差异有统计学意义(t=25.407 8、26.568 2,P<0.05);但药物流产后2周两组患者HCG水平对比差异无统计学意义(t=0.396 3,P>0.05)。观察组患者宫颈炎、阴道出血、阴道炎、颈柱状上皮异位发生率分别为2.50%、0.00%、5.00%、0.00%;对照组患者宫颈炎、阴道出血、阴道炎、颈柱状上皮异位发生率分别为10.00%、7.50%、15.00%、7.50%;两组患者妇科炎症发病率对比差异有统计学意义(P<0.05)。结论在药物流产后及早使用米非司酮干预,能降低药物流产合并妇科炎症发生率,促进患者生活质量改善,值得临床推广。Objective To study the clinical curative effect of mifepristone in preventing the gynecological inflammation of adult females after the drug abortion. Methods 80 cases of adult females admitted and treated in our hospital from January 2015 to January 2017 were selected and randomly divided into two groups with 40 cases in each, the control group were treated with misoprostol and mifepristone, while the observation group continued to take the mifepristone for early drug intervention in 2 weeks after the drug abortion, and the HCG level and onset rate of gynecological inflammation before and after the drug abortion were compared between the two groups, and the gynecological inflammations included the cervicitis, vaginal bleeding, vaginitis, cervical columnar ectopia. Results The HCG levels before drug abortion of the two groups were respectively（13 676.01±3 387.56）IU/L,（13 977.93±3 311.22）IU/L, and the difference was not obvious, without statistical significance（t=0.4031, P〈0.05）; and the HCG levels in the two groups in 2 weeks after drug abortion were respectively（66.98 ±12.38）IU/L,（68.05 ±11.76）IU/L, which obviously decreased compared with those before drug abortion, and the differences between groups were statistically significant（t =25.407 8,26.568 2, P〈0.05）, and the difference in the HCG level between the two groups was not obvious, with statistical significance（t=0.396 3, P〈0.05）, and the incidence rates of cervicitis, vaginal bleeding, vaginitis, cervical columnar ectopia in the observation group and in the control group were respectively 2.50%, 0.00%, 5.00%, 0.00% and 10.00%,7.50%, 15.00%, 7.50%, and the difference in the morbidity of gynecological inflammation between the two groups was not obvious with statistical significance（P〈0.05）. Conclusion Conclusiearly application of mifepristone intervention after the drug abortion can reduce the incidence rate of drug abortion combined with gynecological inflammation, and promote the improvement of quality of life, an

关 键 词：米非司酮 成年女性 药物流产 妇科炎症 

分 类 号：R246.3[医药卫生—针灸推拿学]